The Mouse CD1d Monoclonal Antibody FITC Conjugated (19G11) is a cutting-edge tool for researchers studying CD1d, a pivotal cell surface protein involved in antigen presentation to natural killer T (NKT) cells. This monoclonal antibody, specifically designed for mouse samples, is conjugated with FITC for easy detection and visualization under fluorescence microscopy or flow cytometry. The 19G11 antibody specifically targets the CD1d protein, facilitating the analysis of its expression and localization in a variety of cell types.
CD1d is a key player in the immune system, bridging the innate and adaptive immune responses by presenting lipid antigens to NKT cells. This interaction triggers a rapid and potent immune response, impacting immune surveillance, infection control, and autoimmune diseases. The Mouse CD1d Monoclonal Antibody FITC Conjugated (19G11) provides researchers with a reliable tool to delve into the complexities of CD1d-mediated immune responses, offering insights into immunology, infectious diseases, and autoimmunity research.
Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:
Swissprot:
P11609
Gene ID:
12479
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD1d is a type I transmembrane protein and member of the MHC family, with a molecular weight ranging from 43-49 kD, depending on the glycosylation degree. CD1d is expressed by antigen presenting cells such as dendritic cells, monocytes, macrophages and B cells; also expressed by thymocytes and intestinal epithelial cells. CD1d present glycolipids to iNKT cells that recognize them by their Vα14i TCR.