Purified Anti-Mouse CD119 Antibody [GR-20] (AGEL0433)

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SKU:
AGEL0433
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
GR-20
Conjugation:
Unconjugated
Applications:
FC
Frequently bought together:

Description

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Purified Anti-Mouse CD119 Antibody [GR-20]

The Mouse CD119 Monoclonal Antibody (GR-20, AGEL0433) is a specialized tool for research focusing on CD119, a key receptor involved in immune responses. This monoclonal antibody, generated using mouse cells, exhibits high specificity and sensitivity towards mouse samples, making it a reliable choice for various research applications.CD119, also known as the Interleukin-1 Receptor Type 1, plays a pivotal role in mediating the effects of interleukin-1, a pro-inflammatory cytokine that regulates immune and inflammatory responses. By targeting CD119, researchers can investigate pathways implicated in inflammatory conditions, immune system regulation, and related diseases.

This antibody's ability to bind specifically to CD119 enables precise detection and analysis in different experimental settings, offering valuable insights into the mechanisms underlying immune modulation and inflammation.Scientists studying immune system dynamics, inflammatory diseases, and therapeutic interventions will find the Mouse CD119 Monoclonal Antibody (GR-20, AGEL0433) to be a valuable asset in their research toolkit. Its versatility and reliability make it a valuable resource for advancing our understanding of immune responses and developing novel approaches for managing immune-related disorders.

Product Title:Purified Anti-Mouse CD119 Antibody [GR-20]
SKU:AGEL0433
Size:25µg, 100µg
Clone No:GR-20
Synonyms:Interferon gamma receptor 1;Ifngr1;IFN-gamma-R1;IFN-gamma-R-alpha;CD119;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Purified Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P15261
Gene ID:15979
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CDw119 is a 90 kD immunoglobulin superfamily member, also known as IFN-γRα chain. It is a class II cytokine receptor family member that serves as a IFN-γ-binding chain associated with the IFN-γ β chain also known as AF-1. In addition to ligand binding, CDw119 participates in ligand trafficking. CDw119 is expressed on T and B cells, NK cells, fibroblasts, endothelial, and epithelial cells. Binding of IFN-γ induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-γ initiates and regulates a variety of immune responses.

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