Mouse CD112/Nectin-2 Recombinant Protein (RPES2906)
- SKU:
- RPES2906
- Product type:
- Recombinant Protein
- Host species:
- HEK293 Cells
- Reactivity:
- Mouse
Frequently bought together:
Description
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Mouse CD112/Nectin-2 Recombinant Protein
Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
| Product Name: | Mouse CD112/Nectin-2 Recombinant Protein (RPES2906) |
| Product Code: | RPES2906 |
| Size: | 50µg |
| Species: | Mouse |
| Expressed Host: | HEK293 Cells |
| Synonyms: | AI325026 Protein, AI987993 Protein, Cd112 Protein, MPH Protein, nectin-2 Protein, Pvr Protein, Pvs Protein |
| Accession: | NP_033016.3 |
| Sequence: | Met 1-Gly 351 |
| Fusion tag: | C-His |
| Activity: | Measured by its binding ability in a functional ELISA.1. Immobilized mouse CD112-His at 10 µg/ml (100 ?l/well) can bind biotinylated mouse DNAM1-His with a linear range of 0.156-5.0 µg/ml.2. Immobilized mouse CD112-His at 10 µg/ml (100 ?l/well) can bind mouse DNAM1-Fc with a linear range of 0.03-1.0 µg/ml. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mouse PVRL2 (NP_033016.3) extracellular domain (Met 1-Gly 351) was fused with a polyhistidine tag at the C-terminus. |
| Purity: | > 98 % as determined by SDS-PAGE |
| Mol Mass: | 36 kDa |
| AP Mol Mass: | 40-45 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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