Purified Anti-Mouse CD103 Antibody [M290] (AGEL0330)

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SKU:
AGEL0330
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
M290
Conjugation:
Unconjugated
Applications:
FC
IHC
IP
Frequently bought together:

Description

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Purified Anti-Mouse CD103 Antibody [M290]

The Mouse CD103 Monoclonal Antibody (M290) offered by Assay Genie is a versatile tool for researchers studying immune responses and cell interactions in mice. This monoclonal antibody specifically targets CD103, a cell surface molecule that plays a key role in immune regulation and tissue residency of immune cells.Derived from hybridoma cells, this antibody exhibits high specificity and sensitivity when detecting CD103 expression in various tissues and cell types. It is suitable for a range of applications, including flow cytometry, immunohistochemistry, and immunofluorescence, providing researchers with valuable insights into the distribution and function of CD103-expressing cells.CD103, also known as integrin alpha E, is involved in the regulation of immune responses, particularly in the context of tissue-specific immunity and tolerance induction.

Its expression on immune cells like dendritic cells and T cells is associated with tissue-resident memory responses and immune surveillance in barrier tissues.By utilizing the Mouse CD103 Monoclonal Antibody (M290), researchers can deepen their understanding of immune cell behavior and the mechanisms underlying immune-mediated diseases such as autoimmune disorders, inflammatory conditions, and cancer. This antibody serves as a reliable tool for investigating the role of CD103 in immune homeostasis and disease pathogenesis, ultimately contributing to the development of novel therapeutic strategies targeting immune-mediated disorders.

Product Title:Purified Anti-Mouse CD103 Antibody [M290]
SKU:AGEL0330
Size:25µg, 100µg
Clone No:M290
Synonyms:Integrin alpha-E;Itgae;Integrin alpha M290;CD103;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Purified Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q60677
Gene ID:16407
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

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