APC Anti-Mouse CD103 Antibody [M290] (AGEL1146)

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SKU:
AGEL1146
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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APC Anti-Mouse CD103 Antibody [M290]

The Mouse CD103 Monoclonal Antibody (APC-conjugated, M290) is a cutting-edge tool for researchers studying immune cell biology and immunotherapy. This antibody specifically targets CD103, a cell surface molecule known for its role in immune regulation, particularly in the context of tissue-resident T cells and dendritic cells.Developed with advanced technology, this monoclonal antibody is meticulously validated for optimal performance in flow cytometry and other cellular analysis techniques. Its APC conjugation allows for easy detection and precise quantification of CD103-expressing cells in diverse biological samples. With high specificity and sensitivity, researchers can confidently explore the function and distribution of CD103 in various tissues and experimental systems.

CD103 is a key player in immune surveillance, inflammation, and tolerance within the body. By targeting CD103-expressing cells, researchers can delve into the mechanisms underlying immune responses, tissue integrity, and immune-mediated diseases like cancer, inflammatory bowel disease, and autoimmunity. Insights gained from studying CD103 with this monoclonal antibody can pave the way for novel therapeutic strategies aimed at manipulating immune cell behavior for improved health outcomes.Empower your research with the Mouse CD103 Monoclonal Antibody (APC-conjugated, M290) and unlock new possibilities in understanding and modulating immune responses.

Product Title:APC Anti-Mouse CD103 Antibody [M290]
SKU:AGEL1146
Size:50 Tests, 100 Tests, 200 Tests
Clone No:M290
Synonyms:Integrin alpha-E;Itgae;Integrin alpha M290;CD103;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q60677
Gene ID:16407
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

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