Mouse ANTXR2 Recombinant Protein (RPPB2746)

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SKU:
RPPB2746
Product type:
Recombinant Protein
Size:
5ug
Species:
Mouse
Target:
ANTXR2
Synonyms:
Anthrax toxin receptor 2
Synonyms:
Antxr2
Source:
Sf9 Insect cells
Uniprot:
Q6DFX2
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Description

Product Name:Mouse ANTXR2 Recombinant Protein
Product Code:RPPB2746
Size:5µg
Species:Mouse
Target:ANTXR2
Synonyms:Anthrax toxin receptor 2, Antxr2.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation: ANTXR2 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:QAQEQPSCKK AFDLYFVLDKSGSVANNWIE IYNFVHQLTE RFVSPEMRLS FIVFSSQATI ILPLTGDRYK IGKGLEDLKA VKPVGETYIHEGLKLANEQI QNAGGLKASS IIIALTDGKL DGLVPSYAEN EAKKSRSLGA SVYCVGVLDF EQAQLERIADSKDQVFPVKG GFQALKGIIN SILAQSCTEI LELSPSSVCV GEKFQVVLTG RAVTSISHDG SVLCTFTANSTYTKSEKPVS IQPSSILCPA PVLNKDGETL EVSISYNDGK SAVSRSLTIT ATECTNGLEH HHHHH

Anthrax toxin receptor 2, also known as ANTXR2, takes part in the configuration of little blood vessels (capillaries). ANTXR2 helps the toxin that leads to anthrax to attach to cells and trigger illness. ANTXR2 is necessary for cellular interactions with laminin and the extracellular matrix.

ANTXR2 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 295 amino acids (32-318aa) and having a molecular mass of 31.9kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).ANTXR2 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:ANTXR2: Necessary for cellular interactions with laminin and the extracellular matrix. Defects in ANTXR2 are the cause of infantile systemic hyalinosis (ISH). This autosomal recessive syndrome is similar to JHF, but has an earlier onset and a more severe course. Symptoms appear at birth or within the first months of life, with painful, swollen joint contractures, osteopenia, osteoporosis and livid red hyperpigmentation over bony prominences. Patients develop multiple subcutaneous skin tumors and gingival hypertrophy. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to death within the first 2 years of life. Surviving children may suffer from severely reduced mobility due to joint contractures. Defects in ANTXR2 are the cause of juvenile hyaline fibromatosis (JHF). JHF is an autosomal recessive syndrome that is similar to ISH but takes a milder course. It is characterized by hyaline deposition in the dermis, multiple subcutaneous skin tumors and gingival hypertrophy, followed by progressive joint contractions, osteopenia and osteoporosis that may lead to a severe limitation of mobility. Belongs to the ATR family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 5|5 E3

Cellular Component: cell surface; external side of plasma membrane; integral component of membrane; membrane

Molecular Function:metal ion binding; receptor activity

Biological Process: reproductive process

UniProt Code:Q6DFX2
NCBI GenInfo Identifier:50355939
NCBI Gene ID:71914
NCBI Accession:NP_598499.1
UniProt Secondary Accession:Q6DFX2,Q99L17,
UniProt Related Accession:Q6DFX2
Molecular Weight:53,184 Da
NCBI Full Name:anthrax toxin receptor 2
NCBI Synonym Full Names:anthrax toxin receptor 2
NCBI Official Symbol:Antxr2  
NCBI Official Synonym Symbols:CMG2; CMG-2; cI-35; AW561899; 2310046B19Rik  
NCBI Protein Information:anthrax toxin receptor 2
UniProt Protein Name:Anthrax toxin receptor 2
Protein Family:Anthrax toxin receptor
UniProt Gene Name:Antxr2  
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