MMP7 Antibody (PACO23684)
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주문- SKU:
- PACO23684
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MMP7 Antibody (PACO23684) |
Antibody SKU: | PACO23684 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from human MMP-7. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using MMP-7 antibody. |
![]() | Western blot analysis of extracts from COS7 cells (Lane 2) and HuvEc cells (Lane 3), using MMP-7 antiobdy. The lane on the left is treated with systhesized peptide. |
![]() | Western blot analysis of extracts from COS7 cells, using MMP-7 antibody. |
Background: | Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. |
Synonyms: | PUMP1; PUTATIVE METALLOPROTEINASE I; matrix metalloproteinase 7 (matrilysin; uterine); |
UniProt Protein Function: | MMP7: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Belongs to the peptidase M10A family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Protease; EC 3.4.24.23 Chromosomal Location of Human Ortholog: 11q22.2 Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region Molecular Function:zinc ion binding; metalloendopeptidase activity Biological Process: response to drug; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response to Gram-positive bacterium; antibacterial peptide biosynthetic process; defense response to Gram-negative bacterium; proteolysis; antibacterial peptide secretion; regulation of cell proliferation |
NCBI Summary: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] |
UniProt Code: | P09237 |
NCBI GenInfo Identifier: | 116861 |
NCBI Gene ID: | 4316 |
NCBI Accession: | P09237.1 |
UniProt Secondary Accession: | P09237,Q9BTK9, |
UniProt Related Accession: | P09237 |
Molecular Weight: | 29,677 Da |
NCBI Full Name: | Matrilysin |
NCBI Synonym Full Names: | matrix metallopeptidase 7 (matrilysin, uterine) |
NCBI Official Symbol: | MMP7 |
NCBI Official Synonym Symbols: | MMP-7; MPSL1; PUMP-1 |
NCBI Protein Information: | matrilysin; matrin; pump-1 protease; uterine matrilysin; uterine metalloproteinase; matrix metalloproteinase-7; matrix metalloproteinase 7 (matrilysin, uterine) |
UniProt Protein Name: | Matrilysin |
UniProt Synonym Protein Names: | Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase |
Protein Family: | Matrilysin |
UniProt Gene Name: | MMP7 |
UniProt Entry Name: | MMP7_HUMAN |
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