MMP19 Antibody (PACO23124)
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주문- SKU:
- PACO23124
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MMP19 Antibody (PACO23124) |
Antibody SKU: | PACO23124 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from human MMP-19. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from HuvEc cells, using MMP-19 antibody. |
![]() | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MMP-19 antibody. |
Background: | Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. |
Synonyms: | MATRIX METALLOPROTEINASE 18; FORMERLY; MMP18; FORMERLY; matrix metalloproteinase 19 |
UniProt Protein Function: | MMP19: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients. Belongs to the peptidase M10A family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted; Protease; Secreted, signal peptide; EC 3.4.24.- Chromosomal Location of Human Ortholog: 12q14 Cellular Component: extracellular region Molecular Function:serine-type endopeptidase activity Biological Process: extracellular matrix disassembly Disease: Cavitary Optic Disc Anomalies |
NCBI Summary: | This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013] |
UniProt Code: | Q99542 |
NCBI GenInfo Identifier: | 12643345 |
NCBI Gene ID: | 4327 |
NCBI Accession: | Q99542.1 |
UniProt Secondary Accession: | Q99542,O15278, O95606, Q99580, B4E030, |
UniProt Related Accession: | Q99542 |
Molecular Weight: | 33,793 Da |
NCBI Full Name: | Matrix metalloproteinase-19 |
NCBI Synonym Full Names: | matrix metallopeptidase 19 |
NCBI Official Symbol: | MMP19 |
NCBI Official Synonym Symbols: | CODA; MMP18; RASI-1 |
NCBI Protein Information: | matrix metalloproteinase-19 |
UniProt Protein Name: | Matrix metalloproteinase-19 |
UniProt Synonym Protein Names: | Matrix metalloproteinase RASI; Matrix metalloproteinase-18; MMP-18 |
Protein Family: | Matrix metalloproteinase |
UniProt Gene Name: | MMP19 |
UniProt Entry Name: | MMP19_HUMAN |
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