MGAT3 Antibody (PACO58064)
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주문- SKU:
- PACO58064
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MGAT3 Antibody (PACO58064) |
Antibody SKU: | PACO58064 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:500-1:1000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase protein (435-533AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Mouse kidney tissue. All lanes: MGAT3 antibody at 2.35µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 62 kDa. Observed band size: 62 kDa. |
![]() | IHC image of PACO58064 diluted at 1:600 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in β 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. |
Synonyms: | Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC 2.4.1.144) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III) (GNT-III) (GlcNAc-T III) (N-acetylglucosaminyltransferase III), MGAT3, GGNT3 |
UniProt Protein Function: | MGAT3: It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Belongs to the glycosyltransferase 17 family. |
UniProt Protein Details: | Protein type:Glycan Metabolism - N-glycan biosynthesis; Transferase; EC 2.4.1.144; Membrane protein, integral Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: Golgi membrane; integral to membrane Molecular Function:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity Biological Process: cellular protein metabolic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification |
NCBI Summary: | There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q09327 |
NCBI GenInfo Identifier: | 61252497 |
NCBI Gene ID: | 4248 |
NCBI Accession: | Q09327.3 |
UniProt Secondary Accession: | Q09327,Q14CK5, Q6IC49, Q9UH32, A6NGD0, |
UniProt Related Accession: | Q09327 |
Molecular Weight: | 61,313 Da |
NCBI Full Name: | Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
NCBI Synonym Full Names: | mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase |
NCBI Official Symbol: | MGAT3 |
NCBI Official Synonym Symbols: | GNT3; GNT-III |
NCBI Protein Information: | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase; GlcNAc-T III; N-acetylglucosaminyltransferase III; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III |
UniProt Protein Name: | Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
UniProt Synonym Protein Names: | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III; GNT-III; GlcNAc-T III; N-acetylglucosaminyltransferase III |
Protein Family: | Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
UniProt Gene Name: | MGAT3 |
UniProt Entry Name: | MGAT3_HUMAN |