MFSD2A Antibody (PACO20007)
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주문- SKU:
- PACO20007
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MFSD2A Antibody (PACO20007) |
Antibody SKU: | PACO20007 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human MFSD2A |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20007(MFSD2A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: Human thyroid cancer tissue, Primary antibody: PACO20007(MFSD2A Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20007(MFSD2A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | MFSD2 (major facilitator superfamily domain containing 2), also known as MFSD2A, is a 543 amino acid, multi-pass membrane protein of the endoplasmic reticulum that is involved in beta-adrenergic signaling during thermogenesis. Existing as three alternatively spliced isoforms, MFSD2 plays a role in G1 regulation and is encoded by a gene that maps to human chromosome 1p34.2. Human chromosome 1 spans 260 million base pairs, contains over 3,000 genes, comprises nearly 8% of the human genome and houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. |
Synonyms: | major facilitator superfamily domain containing 2A |
UniProt Protein Function: | TBX5: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Defects in TBX5 are the cause of Holt-Oram syndrome (HOS). HOS is a developmental disorder affecting the heart and upper limbs. It is characterized by thumb anomaly and atrial septal defects. 2 isoforms of the human protein are produced by alternative splicing.Protein type: DNA-binding; Transcription factorChromosomal Location of Human Ortholog: 12q24.1Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleusMolecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity; transcription factor bindingBiological Process: embryonic forelimb morphogenesis; pericardium development; transcription initiation from RNA polymerase II promoter; heart development; positive regulation of transcription, DNA-dependent; pattern specification process; cardiac muscle cell differentiation; forelimb morphogenesis; negative regulation of cell proliferation; cell-cell signaling; apoptotic nuclear changes; negative regulation of cardiac muscle cell proliferation; positive regulation of cardioblast differentiation; morphogenesis of an epithelium; gene expression; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell migration; lung development; embryonic limb morphogenesis; positive regulation of cardiac muscle cell proliferationDisease: Holt-oram Syndrome |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is a transmembrane protein and sodium-dependent lysophosphatidylcholine transporter. The encoded protein is involved in the establishment of the blood-brain barrier and is required for brain growth and function. Defects in this gene are a cause of a progressive microcephaly syndrome. [provided by RefSeq, Mar 2017] |
UniProt Code: | Q8NA29 |
NCBI GenInfo Identifier: | 211063479 |
NCBI Gene ID: | 84879 |
NCBI Accession: | NP_001129965 |
UniProt Secondary Accession: | Q8NA29 |
UniProt Related Accession: | Q8NA29 |
Molecular Weight: | 58 |
NCBI Full Name: | sodium-dependent lysophosphatidylcholine symporter 1 isoform 1 |
NCBI Synonym Full Names: | major facilitator superfamily domain containing 2A |
NCBI Official Symbol: | MFSD2A |
NCBI Official Synonym Symbols: | NLS1; MFSD2; MCPH15 |
NCBI Protein Information: | sodium-dependent lysophosphatidylcholine symporter 1 |
UniProt Protein Name: | T-box transcription factor TBX5 |
UniProt Synonym Protein Names: | |
Protein Family: | T-box transcription factor |
UniProt Gene Name: | TBX5 |
UniProt Entry Name: | TBX5_HUMAN |