UniProt Protein Function: | MFNG: Glycosyltransferase involved in the elongation of O- linked ligands to activate Notch signaling. Possesses fucose- specific beta-1,3-N-acetylglucosaminyltransferase activity. Belongs to the glycosyltransferase 31 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transferase; Membrane protein, integral; EC 2.4.1.222Chromosomal Location of Human Ortholog: 22q12Cellular Component: extracellular space; integral to Golgi membraneMolecular Function: metal ion binding; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activityBiological Process: positive regulation of protein binding; metabolic process; pattern specification process; positive regulation of Notch signaling pathway |
UniProt Protein Details: | |
NCBI Summary: | This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the LFNG (GeneID: 3955) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene may control Notch signaling in claudin-low breast cancer. [provided by RefSeq, May 2018] |
UniProt Code: | O00587 |
NCBI GenInfo Identifier: | 21536461 |
NCBI Gene ID: | 4242 |
NCBI Accession: | NP_002396 |
UniProt Secondary Accession: | O00587 |
UniProt Related Accession: | O00587 |
Molecular Weight: | 36kDa |
NCBI Full Name: | beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform 1 |
NCBI Synonym Full Names: | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
NCBI Official Symbol: | MFNG |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | beta-1,3-N-acetylglucosaminyltransferase manic fringe |
UniProt Protein Name: | Beta-1,3-N-acetylglucosaminyltransferase manic fringe |
UniProt Synonym Protein Names: | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
Protein Family: | Beta-1,3-N-acetylglucosaminyltransferase manic fringe |
UniProt Gene Name: | MFNG |
UniProt Entry Name: | MFNG_HUMAN |