MED24 Antibody (PACO23176)
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주문- SKU:
- PACO23176
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | MED24 Antibody (PACO23176) |
Antibody SKU: | PACO23176 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IF:1:100-1:500 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from internal of human MED24. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from 293 cells, using MED24 antibody. |
![]() | Immunofluorescence analysis of HUVEC cells, using MED24 antibody. |
Background: | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
Synonyms: | 100 kDa thyroid hormone receptor associated protein; ARC100; Activator-recruited cofactor 100 kDa component; DRIP100; KIAA0130 |
UniProt Protein Function: | Trap100: a transcriptional coactivator protein of the thyroid hormone receptor-associated protein (TRAP) family. Forms a complex with the thyroid hormone receptor (TR) and markedly enhance TR-mediated transcription in vitro. Interacts and co-precipitates with Trap220 but does not directly bind nuclear hormone receptors. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 17q21.1 Cellular Component: nucleoplasm; nucleus; Srb-mediator complex; ubiquitin ligase complex Molecular Function:histone acetyltransferase activity; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; receptor activity; thyroid hormone receptor binding; transcription cofactor activity; vitamin D receptor binding Biological Process: androgen receptor signaling pathway; gene expression; histone acetylation; positive regulation of transcription, DNA-dependent; protein heterooligomerization; protein ubiquitination; regulation of transcription from RNA polymerase II promoter; stem cell maintenance; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter |
NCBI Summary: | This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O75448 |
NCBI GenInfo Identifier: | 21617826 |
NCBI Gene ID: | 9862 |
NCBI Accession: | O75448.1 |
UniProt Secondary Accession: | O75448,Q14143, Q9NNY5, A8K4S5, B3KMR9, |
UniProt Related Accession: | O75448 |
Molecular Weight: | 108,938 Da |
NCBI Full Name: | Mediator of RNA polymerase II transcription subunit 24 |
NCBI Synonym Full Names: | mediator complex subunit 24 |
NCBI Official Symbol: | MED24 |
NCBI Official Synonym Symbols: | MED5; CRSP4; ARC100; THRAP4; CRSP100; DRIP100; TRAP100 |
NCBI Protein Information: | mediator of RNA polymerase II transcription subunit 24 |
UniProt Protein Name: | Mediator of RNA polymerase II transcription subunit 24 |
UniProt Synonym Protein Names: | Activator-recruited cofactor 100 kDa component; ARC100; Cofactor required for Sp1 transcriptional activation subunit 4; CRSP complex subunit 4; Mediator complex subunit 24; Thyroid hormone receptor-associated protein 4; Thyroid hormone receptor-associated protein complex 100 kDa component; Trap100; hTRAP100; Vitamin D3 receptor-interacting protein complex 100 kDa component; DRIP100 |
Protein Family: | Mediator of RNA polymerase II transcription |
UniProt Gene Name: | MED24 |
UniProt Entry Name: | MED24_HUMAN |