MCUB Antibody (PACO41186)
- SKU:
- PACO41186
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | MCUB Antibody (PACO41186) |
| Antibody SKU: | PACO41186 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Calcium uniporter regulatory subunit MCUb, mitochondrial protein (89-219AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO41186 at dilution of 1:100. |
 | Immunofluorescent analysis of A549 cells using PACO41186 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. |
| Synonyms: | Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUb) (Coiled-coil domain-containing protein 109B), MCUB, CCDC109B |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9NWR8 |
| NCBI GenInfo Identifier: | 194018570 |
| NCBI Gene ID: | 55013 |
| NCBI Accession: | NP_060388.2 |
| UniProt Secondary Accession: | Q9NWR8,Q6IAC1, A8K4Y3 |
| UniProt Related Accession: | Q9NWR8 |
| Molecular Weight: | 39,082 Da |
| NCBI Full Name: | mitochondrial calcium uniporter regulatory subunit MCUb |
| NCBI Synonym Full Names: | coiled-coil domain containing 109B |
| NCBI Official Symbol: | CCDC109B |
| NCBI Official Synonym Symbols: | EMRE; MCUb |
| NCBI Protein Information: | mitochondrial calcium uniporter regulatory subunit MCUb; essential MCU regulator; coiled-coil domain-containing protein 109B |
| UniProt Protein Name: | Mitochondrial calcium uniporter regulatory subunit MCUb |
| UniProt Synonym Protein Names: | Coiled-coil domain-containing protein 109B; Essential MCU regulator; EMRE |
| Protein Family: | Calcium uniporter regulatory |
| UniProt Gene Name: | CCDC109B |
| UniProt Entry Name: | MCUB_HUMAN |
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