MCM4 Antibody (PACO04307)
- SKU:
- PACO04307
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MCM4 Antibody |
Antibody SKU: | PACO04307 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse |
Immunogen: | synthesized peptide derived from human MCM4 around the non-phosphorylation site of S54. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | MCM4; CDC21; DNA replication licensing factor MCM4; CDC21 homolog; P1-CDC21 |
UniProt Protein Function: | MCM4: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. The MCM hexameric protein complex is a key component of the pre-replication complex. The complex consisting of this protein and MCM2, 6 and 7 possesses DNA helicase activity. Phosphorylation by CDC2 reduces the DNA helicase activity and chromatin binding of the complex. |
UniProt Protein Details: | Protein type:EC 3.6.4.12; DNA replication Chromosomal Location of Human Ortholog: 8q11.2 Cellular Component: MCM complex; membrane; nuclear chromosome, telomeric region; nucleoplasm Molecular Function:ATP-dependent DNA helicase activity; protein binding Biological Process: DNA replication; G1/S transition of mitotic cell cycle Disease: Natural Killer Cell And Glucocorticoid Deficiency With Dna Repair Defect |
NCBI Summary: | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] |
UniProt Code: | P33991 |
NCBI GenInfo Identifier: | 68571766 |
NCBI Gene ID: | 4173 |
NCBI Accession: | P33991.5 |
UniProt Secondary Accession: | P33991,Q8NEH1, Q99658, |
UniProt Related Accession: | P33991 |
Molecular Weight: | 96,558 Da |
NCBI Full Name: | DNA replication licensing factor MCM4 |
NCBI Synonym Full Names: | minichromosome maintenance complex component 4 |
NCBI Official Symbol: | MCM4 |
NCBI Official Synonym Symbols: | NKCD; CDC21; CDC54; NKGCD; hCdc21; P1-CDC21 |
NCBI Protein Information: | DNA replication licensing factor MCM4 |
UniProt Protein Name: | DNA replication licensing factor MCM4 |
UniProt Synonym Protein Names: | CDC21 homolog; P1-CDC21 |
Protein Family: | DNA replication licensing factor |
UniProt Gene Name: | MCM4 |
UniProt Entry Name: | MCM4_HUMAN |