MAS1 Antibody (PACO43834)
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주문- SKU:
- PACO43834
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MAS1 Antibody (PACO43834) |
Antibody SKU: | PACO43834 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Proto-oncogene Mas protein (246-325AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43834 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO43834 at dilution of 1:100. |
Background: | Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. |
Synonyms: | Proto-oncogene Mas, MAS1, MAS |
UniProt Protein Function: | MAS1: Receptor for angiotensin 1-7. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:GPCR, family 1; Oncoprotein; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 6q25.3-q26 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:angiotensin receptor activity; angiotensin type II receptor activity; G-protein coupled receptor activity; peptide binding; protein binding Biological Process: anatomical structure morphogenesis; cell proliferation; G-protein coupled receptor protein signaling pathway |
NCBI Summary: | This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012] |
UniProt Code: | P04201 |
NCBI GenInfo Identifier: | 135920 |
NCBI Gene ID: | 4142 |
NCBI Accession: | P04201.1 |
UniProt Secondary Accession: | P04201,Q2TBC9, Q6FG47, E1P5B3, |
UniProt Related Accession: | P04201 |
Molecular Weight: | 37,465 Da |
NCBI Full Name: | Proto-oncogene Mas |
NCBI Synonym Full Names: | MAS1 proto-oncogene, G protein-coupled receptor |
NCBI Official Symbol: | MAS1 |
NCBI Official Synonym Symbols: | MAS; MGRA |
NCBI Protein Information: | proto-oncogene Mas |
UniProt Protein Name: | Proto-oncogene Mas |
Protein Family: | Proto-oncogene |
UniProt Gene Name: | MAS1 |
UniProt Entry Name: | MAS_HUMAN |