MANF Antibody (PACO19140)
- SKU:
- PACO19140
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MANF Antibody (PACO19140) |
Antibody SKU: | PACO19140 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human MANF |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO19140(MANF Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19140(MANF Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. |
Synonyms: | mesencephalic astrocyte-derived neurotrophic factor |
UniProt Protein Function: | ARMET: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Belongs to the ARMET family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: nucleus Disease: Pancreatic Cancer |
NCBI Summary: | The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014] |
UniProt Code: | P55145 |
NCBI GenInfo Identifier: | 332278201 |
NCBI Gene ID: | 7873 |
NCBI Accession: | P55145.3 |
UniProt Secondary Accession: | P55145,Q14CX4, Q86U67, Q96IS4, |
UniProt Related Accession: | P55145 |
Molecular Weight: | 20,700 Da |
NCBI Full Name: | Mesencephalic astrocyte-derived neurotrophic factor |
NCBI Synonym Full Names: | mesencephalic astrocyte derived neurotrophic factor |
NCBI Official Symbol: | MANF |
NCBI Official Synonym Symbols: | ARP; ARMET |
NCBI Protein Information: | mesencephalic astrocyte-derived neurotrophic factor |
UniProt Protein Name: | Mesencephalic astrocyte-derived neurotrophic factor |
UniProt Synonym Protein Names: | Arginine-rich protein; Protein ARMET |
Protein Family: | MANF/CDNF-like protein |
UniProt Gene Name: | MANF |
UniProt Entry Name: | MANF_HUMAN |
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