MAN2A1 Antibody (PACO52294)
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주문- SKU:
- PACO52294
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MAN2A1 Antibody (PACO52294) |
Antibody SKU: | PACO52294 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Alpha-mannosidase 2 protein (31-181AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: HEK293 whole cell lysate, HepG2 whole cell lysate. All lanes: MAN2A1 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 132 kDa. Observed band size: 150 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human cervical cancer using PACO52294 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human lung cancer using PACO52294 at dilution of 1:100. |
Background: | Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. |
Synonyms: | Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase α class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase), MAN2A1, MANA2 |
UniProt Protein Function: | MAN2A1: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. Belongs to the glycosyl hydrolase 38 family. |
UniProt Protein Details: | Protein type:Hydrolase; Membrane protein, integral; EC 3.2.1.114; Glycan Metabolism - N-glycan biosynthesis Chromosomal Location of Human Ortholog: 5q21.3 Cellular Component: Golgi membrane; membrane Molecular Function:mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity Biological Process: mannose metabolic process; N-glycan processing; protein deglycosylation |
NCBI Summary: | This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013] |
UniProt Code: | Q16706 |
NCBI GenInfo Identifier: | 146345453 |
NCBI Gene ID: | 4124 |
NCBI Accession: | Q16706.2 |
UniProt Secondary Accession: | Q16706,Q16767, |
UniProt Related Accession: | Q16706 |
Molecular Weight: | 131,141 Da |
NCBI Full Name: | Alpha-mannosidase 2 |
NCBI Synonym Full Names: | mannosidase alpha class 2A member 1 |
NCBI Official Symbol: | MAN2A1 |
NCBI Official Synonym Symbols: | MANA2; MANII; GOLIM7; AMan II |
NCBI Protein Information: | alpha-mannosidase 2 |
UniProt Protein Name: | Alpha-mannosidase 2 |
UniProt Synonym Protein Names: | Golgi alpha-mannosidase II; AMan II; Man II; Mannosidase alpha class 2A member 1; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase |
UniProt Gene Name: | MAN2A1 |
UniProt Entry Name: | MA2A1_HUMAN |
Antibodies |
Anti-MAN2A1 Antibody (CAB10227) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |