LRIG1 Antibody (PACO18164)
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주문- SKU:
- PACO18164
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | LRIG1 Antibody (PACO18164) |
Antibody SKU: | PACO18164 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human LRIG1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18164(LRIG1 Antibody) at dilution 1/120, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene. It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR-family , MET and RET. Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. |
Synonyms: | leucine-rich repeats and immunoglobulin-like domains 1 |
UniProt Protein Function: | LRIG1: a singhle-pass type I membrane protein that acts as a feedback negative regulator of signaling by receptor tyrosine kinases. Regulates cadherin-dependent contact inhibition. Interacts with EGFR, HER2, -3, and -4. Two isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 3p14.1 Cellular Component: plasma membrane |
UniProt Code: | Q96JA1 |
NCBI GenInfo Identifier: | 143811415 |
NCBI Gene ID: | 26018 |
NCBI Accession: | Q96JA1.2 |
UniProt Secondary Accession: | Q96JA1,Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4, |
UniProt Related Accession: | Q96JA1 |
Molecular Weight: | 119kDa |
NCBI Full Name: | Leucine-rich repeats and immunoglobulin-like domains protein 1 |
NCBI Synonym Full Names: | leucine rich repeats and immunoglobulin like domains 1 |
NCBI Official Symbol: | LRIG1 |
NCBI Official Synonym Symbols: | LIG1; LIG-1 |
NCBI Protein Information: | leucine-rich repeats and immunoglobulin-like domains protein 1 |
UniProt Protein Name: | Leucine-rich repeats and immunoglobulin-like domains protein 1 |
Protein Family: | Leucine-rich repeats and immunoglobulin-like domains protein |
UniProt Gene Name: | LRIG1 |