LRAT Antibody (PACO63347)
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주문- SKU:
- PACO63347
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | LRAT Antibody (PACO63347) |
Antibody SKU: | PACO63347 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Lecithin retinol acyltransferase protein (24-182AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: COLO205 whole cell lysate, MCF-7 whole cell lysate. All lanes: LRAT antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 26 kDa. Observed band size: 50 kDa. |
Background: | Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. |
Synonyms: | Lecithin retinol acyltransferase (EC 2.3.1.135) (Phosphatidylcholine--retinol O-acyltransferase), LRAT |
UniProt Protein Function: | LRAT: Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. Defects in LRAT are a cause of Leber congenital amaurosis type 14 (LCA14). It is a severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus. Belongs to the H-rev107 family. |
UniProt Protein Details: | Protein type:EC 2.3.1.135; Transferase; Cofactor and Vitamin Metabolism - retinol; Membrane protein, integral Chromosomal Location of Human Ortholog: 4q32.1 Cellular Component: multivesicular body; endoplasmic reticulum membrane; rough endoplasmic reticulum; perinuclear region of cytoplasm; integral to membrane Molecular Function:retinoic acid binding; transferase activity, transferring acyl groups; retinol binding; phosphatidylcholine-retinol O-acyltransferase activity Biological Process: positive regulation of lipid transport; phototransduction, visible light; visual perception; retinol metabolic process; retinoic acid metabolic process; retinoid metabolic process; vitamin A metabolic process Disease: Leber Congenital Amaurosis 14; Retinitis Pigmentosa |
NCBI Summary: | The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] |
UniProt Code: | O95237 |
NCBI GenInfo Identifier: | 46576867 |
NCBI Gene ID: | 9227 |
NCBI Accession: | O95237.2 |
UniProt Secondary Accession: | O95237,Q8N716, A8K983, |
UniProt Related Accession: | O95237 |
Molecular Weight: | 25,703 Da |
NCBI Full Name: | Lecithin retinol acyltransferase |
NCBI Synonym Full Names: | lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) |
NCBI Official Symbol: | LRAT |
NCBI Official Synonym Symbols: | LCA14 |
NCBI Protein Information: | lecithin retinol acyltransferase |
UniProt Protein Name: | Lecithin retinol acyltransferase |
UniProt Synonym Protein Names: | Phosphatidylcholine--retinol O-acyltransferase |
Protein Family: | Lecithin retinol acyltransferase |
UniProt Gene Name: | LRAT |
UniProt Entry Name: | LRAT_HUMAN |
Antibodies |
Anti-LRAT Antibody (CAB13175) |
Anti-LRAT Antibody (CAB13256) |
Anti-LRAT Antibody (CAB6647) |
LRAT Antibody (PACO01029) |
LRAT Antibody (PACO10284) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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