LOX Antibody (PACO17555)
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주문- SKU:
- PACO17555
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | LOX Antibody (PACO17555) |
Antibody SKU: | PACO17555 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human LOX |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO17555(LOX Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane: 293T cells, Primary antibody: PACO17555(LOX Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO17555(LOX Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | Lysyl oxidase |
UniProt Protein Function: | LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family. |
UniProt Protein Details: | Protein type:EC 1.4.3.13; Secreted; Secreted, signal peptide; Oxidoreductase Chromosomal Location of Human Ortholog: 5q23.2 Cellular Component: extracellular region Molecular Function:protein binding Biological Process: extracellular matrix organization and biogenesis; protein modification process Disease: Cutis Laxa, Autosomal Recessive, Type Ia |
NCBI Summary: | This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016] |
UniProt Code: | P28300 |
NCBI GenInfo Identifier: | 417269 |
NCBI Gene ID: | 4015 |
NCBI Accession: | P28300.2 |
UniProt Secondary Accession: | P28300,Q5FWF0, B2R5Q3, |
UniProt Related Accession: | P28300 |
Molecular Weight: | 46,944 Da |
NCBI Full Name: | Protein-lysine 6-oxidase |
NCBI Synonym Full Names: | lysyl oxidase |
NCBI Official Symbol: | LOX |
NCBI Protein Information: | protein-lysine 6-oxidase |
UniProt Protein Name: | Protein-lysine 6-oxidase |
UniProt Synonym Protein Names: | Lysyl oxidase |
Protein Family: | Linoleate 9/13-lipoxygenase |
UniProt Gene Name: | LOX |
UniProt Entry Name: | LYOX_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |