LONP1 Antibody (PACO19951)
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주문- SKU:
- PACO19951
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | LONP1 Antibody (PACO19951) |
Antibody SKU: | PACO19951 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human LONP1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO19951(LONP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 6%SDS-PAGE,Lysate: 40 μg,Lane 1-5: A431 cells, NIH/3T3 cells, HepG2 cells, Mouse liver tissue, Hela cells,Primary antibody: PACO19951(LONP1 Antibody) at dilution 1/250 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19951(LONP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. |
Synonyms: | lon peptidase 1, mitochondrial |
UniProt Protein Function: | PRSS15: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single- stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site- specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein. Belongs to the peptidase S16 family. |
UniProt Protein Details: | Protein type:RNA-binding; DNA-binding; Mitochondrial; EC 3.4.21.-; Protease Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: mitochondrion; membrane; mitochondrial matrix; cytoplasm Molecular Function:G-quadruplex DNA binding; protein binding; single-stranded RNA binding; sequence-specific DNA binding; ATP-dependent peptidase activity; serine-type endopeptidase activity; ADP binding; ATP binding; single-stranded DNA binding Biological Process: mitochondrion organization and biogenesis; mitochondrial genome maintenance; proteolysis involved in cellular protein catabolic process; misfolded or incompletely synthesized protein catabolic process; response to hypoxia; response to hormone stimulus; chaperone-mediated protein complex assembly; mitochondrial DNA metabolic process; protein homooligomerization; response to aluminum ion; aging Disease: Codas Syndrome |
UniProt Code: | P36776 |
NCBI GenInfo Identifier: | 12644239 |
NCBI Gene ID: | |
NCBI Accession: | P36776.2 |
Molecular Weight: | |
NCBI Full Name: | Lon protease homolog, mitochondrial |
UniProt Protein Name: | Lon protease homolog, mitochondrial |
UniProt Synonym Protein Names: | LONHsLon protease-like protein; Mitochondrial ATP-dependent protease Lon; Serine protease 15 |
UniProt Gene Name: | LONP1 |
UniProt Entry Name: | LONM_HUMAN |