LMNB2 Antibody (PACO48386)
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주문- SKU:
- PACO48386
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | LMNB2 Antibody (PACO48386) |
Antibody SKU: | PACO48386 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Lamin-B2 protein (442-615AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human glioma using PACO48386 at dilution of 1:100. |
![]() | Immunofluorescent analysis of HepG2 cells using PACO48386 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. |
Synonyms: | Lamin-B2, LMNB2, LMN2 |
UniProt Protein Function: | Lamin B2: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Lamin B2 may be lost during the follicle centre stage of B-cell differentiation in humans. Nuclear lamins are cleaved by caspases during apoptosis. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: lamin filament; nuclear inner membrane Molecular Function:structural molecule activity Disease: Lipodystrophy, Partial, Acquired, Susceptibility To |
UniProt Code: | Q03252 |
NCBI GenInfo Identifier: | 23503078 |
NCBI Gene ID: | |
NCBI Accession: | Q03252.3 |
Molecular Weight: | |
NCBI Full Name: | Lamin-B2 |
UniProt Protein Name: | Lamin-B2 |
Protein Family: | Lamin |
UniProt Gene Name: | LMNB2 |
UniProt Entry Name: | LMNB2_HUMAN |