LIPC Antibody (PACO61306)
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주문- SKU:
- PACO61306
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | LIPC Antibody (PACO61306) |
Antibody SKU: | PACO61306 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Hepatic triacylglycerol lipase protein (23-217AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO61306 diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin. |
Synonyms: | Hepatic triacylglycerol lipase, HL, Hepatic lipase, Lipase member C, LIPC, HTGL |
UniProt Protein Function: | LIPC: Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin. Defects in LIPC are the cause of hepatic lipase deficiency (HL deficiency). A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins. Belongs to the AB hydrolase superfamily. Lipase family. |
UniProt Protein Details: | Protein type:Secreted; EC 3.1.1.3; Secreted, signal peptide; Lipid Metabolism - glycerolipid; Phospholipase Chromosomal Location of Human Ortholog: 15q21-q23 Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space Molecular Function:apolipoprotein binding; low-density lipoprotein binding; phospholipase activity; triacylglycerol lipase activity Biological Process: cholesterol homeostasis; fatty acid biosynthetic process; lipid digestion; reverse cholesterol transport; triacylglycerol catabolic process Disease: Diabetes Mellitus, Noninsulin-dependent; Hepatic Lipase Deficiency; High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 12 |
NCBI Summary: | LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008] |
UniProt Code: | P11150 |
NCBI GenInfo Identifier: | 317373430 |
NCBI Gene ID: | 3990 |
NCBI Accession: | P11150.3 |
UniProt Secondary Accession: | P11150,O43571, P78529, Q99465, A2RUB4, A8K9B6, |
UniProt Related Accession: | P11150 |
Molecular Weight: | 55,914 Da |
NCBI Full Name: | Hepatic triacylglycerol lipase |
NCBI Synonym Full Names: | lipase C, hepatic type |
NCBI Official Symbol: | LIPC |
NCBI Official Synonym Symbols: | HL; HTGL; LIPH; HDLCQ12 |
NCBI Protein Information: | hepatic triacylglycerol lipase |
UniProt Protein Name: | Hepatic triacylglycerol lipase |
UniProt Synonym Protein Names: | Lipase member C |
Protein Family: | Spore germination lipase |
UniProt Gene Name: | LIPC |
UniProt Entry Name: | LIPC_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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