| Background: | Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (By similarity). Binds iron through association with 2,5-dihydroxybenzoic acid, (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberculosis (By similarity). |
| Synonyms: | Neutrophil gelatinase-associated lipocalin (NGAL) (Alpha-2-microglobulin-related protein) (Alpha-2U globulin-related protein) (Lipocalin-2) (Siderocalin LCN2) (p25), Lcn2 |
| UniProt Protein Function: | LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transporter; Apoptosis; Secreted, signal peptide; Secreted Cellular Component: extracellular space; cell; extracellular region; cytosol Molecular Function:protein homodimerization activity; protease binding; transporter activity; iron ion binding Biological Process: response to drug; response to nutrient levels; response to mycotoxin; response to virus; positive regulation of cell projection organization and biogenesis; response to herbicide; cellular response to nutrient levels; iron ion homeostasis; response to bacterium; siderophore transport; innate immune response; ion transport; response to oxidative stress |
| NCBI Summary: | mouse homolog plays a role in IL3 withdrawal-induced apoptosis [RGD, Feb 2006] |
| UniProt Code: | P30152 |
| NCBI GenInfo Identifier: | 306526224 |
| NCBI Gene ID: | 170496 |
| NCBI Accession: | P30152.2 |
| UniProt Secondary Accession: | P30152,Q5HZF1, |
| UniProt Related Accession: | P30152 |
| Molecular Weight: | 22,476 Da |
| NCBI Full Name: | Neutrophil gelatinase-associated lipocalin |
| NCBI Synonym Full Names: | lipocalin 2 |
| NCBI Official Symbol: | Lcn2 |
| NCBI Official Synonym Symbols: | Sip24 |
| NCBI Protein Information: | neutrophil gelatinase-associated lipocalin; p25; NGAL; lipocalin-2; siderocalin LCN2; lipocalin 2 (oncogene 24p3); alpha-2U globulin-related protein; alpha-2-microglobulin-related protein |
| UniProt Protein Name: | Neutrophil gelatinase-associated lipocalin |
| UniProt Synonym Protein Names: | Alpha-2-microglobulin-related protein; Alpha-2U globulin-related protein; Lipocalin-2; Siderocalin LCN2; p25 |
| Protein Family: | Neutrophil gelatinase-associated lipocalin |
| UniProt Gene Name: | Lcn2 |
| UniProt Entry Name: | NGAL_RAT |
