LAMB3 Antibody (PACO16607)
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주문- SKU:
- PACO16607
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | LAMB3 Antibody (PACO16607) |
Antibody SKU: | PACO16607 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human LAMB3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: PC3 cells, Primary antibody: PACO16607(LAMB3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human sarcoma tissue using PACO16607(LAMB3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a β subunit laminin, which together with an α and a γ subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. |
Synonyms: | laminin, β 3 |
UniProt Protein Function: | LAMB3: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMB3 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB); also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs usually within the first six months of life. Occasionally, children survive to teens. H-JEB is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. Defects in LAMB3 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). GABEB is a non- lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted Chromosomal Location of Human Ortholog: 1q32 Cellular Component: laminin-5 complex; extracellular region Molecular Function:protein binding; protein complex binding; structural molecule activity Biological Process: extracellular matrix disassembly; hemidesmosome assembly; extracellular matrix organization and biogenesis; epidermis development; brown fat cell differentiation; cell adhesion Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type; Epidermolysis Bullosa, Junctional, Herlitz Type; Amelogenesis Imperfecta, Type Ia |
NCBI Summary: | The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13751 |
NCBI GenInfo Identifier: | 62868215 |
NCBI Gene ID: | 3914 |
NCBI Accession: | NP_000219.2 |
UniProt Secondary Accession: | Q13751,O14947, Q14733, Q9UJK4, Q9UJL1, D3DT88, |
UniProt Related Accession: | Q13751 |
Molecular Weight: | 129,572 Da |
NCBI Full Name: | laminin subunit beta-3 |
NCBI Synonym Full Names: | laminin, beta 3 |
NCBI Official Symbol: | LAMB3 |
NCBI Official Synonym Symbols: | LAM5; LAMNB1; BM600-125KDA |
NCBI Protein Information: | laminin subunit beta-3; nicein-125kDa; kalinin-140kDa; kalinin B1 chain; laminin B1k chain; laminin S B3 chain; nicein subunit beta; kalinin subunit beta; epiligrin subunit bata; laminin-5 subunit beta; laminin, beta 3 (nicein (125kD), kalinin (140kD), BM600 (125kD)) |
UniProt Protein Name: | Laminin subunit beta-3 |
UniProt Synonym Protein Names: | Epiligrin subunit bata; Kalinin B1 chain; Kalinin subunit beta; Laminin B1k chain; Laminin-5 subunit beta; Nicein subunit beta |
Protein Family: | Laminin |
UniProt Gene Name: | LAMB3 |
UniProt Entry Name: | LAMB3_HUMAN |
Antibodies | ELISA Kits |
Anti-LAMB3 Antibody (CAB13663) | Human LAMB3 protein ELISA Kit |
Anti-LAMB3 Antibody (CAB8127) | Human Laminin subunit beta-3 (LAMB3) ELISA Kit |
LAMB3 Antibody (PACO04215) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |