KYNU Antibody (PACO46546)
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주문- SKU:
- PACO46546
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | KYNU Antibody (PACO46546) |
Antibody SKU: | PACO46546 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Kynureninase protein (99-214AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Mouse spleen tissue. All lanes: KYNU antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 52, 35 kDa. Observed band size: 52 kDa.. |
![]() | Immunofluorescent analysis of MCF-7 cells using PACO46546 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human heart tissue using PACO46546 at dilution of 1:100. |
Background: | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid, (AA) and 3-hydroxyanthranilic acid, (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. |
Synonyms: | Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase), KYNU |
UniProt Protein Function: | KYNU: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively. Belongs to the kynureninase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.7.1.3; Mitochondrial; Amino Acid Metabolism - tryptophan; Hydrolase Chromosomal Location of Human Ortholog: 2q22.2 Cellular Component: nucleoplasm; mitochondrion; cytoplasm; cytosol Molecular Function:protein homodimerization activity; kynureninase activity; pyridoxal phosphate binding Biological Process: anthranilate metabolic process; tryptophan catabolic process to acetyl-CoA; tryptophan catabolic process to kynurenine; quinolinate biosynthetic process; tryptophan catabolic process Disease: Hydroxykynureninuria |
NCBI Summary: | Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010] |
UniProt Code: | Q16719 |
NCBI GenInfo Identifier: | 3913982 |
NCBI Gene ID: | 8942 |
NCBI Accession: | Q16719.1 |
UniProt Secondary Accession: | Q16719,Q6I9T2, Q9BVW3, B2RCZ5, D3DP79, |
UniProt Related Accession: | Q16719 |
Molecular Weight: | 34,635 Da |
NCBI Full Name: | Kynureninase |
NCBI Synonym Full Names: | kynureninase |
NCBI Official Symbol: | KYNU |
NCBI Protein Information: | kynureninase; KYNU; L-kynurenine hydrolase |
UniProt Protein Name: | Kynureninase |
UniProt Synonym Protein Names: | L-kynurenine hydrolase |
UniProt Gene Name: | KYNU |
UniProt Entry Name: | KYNU_HUMAN |
Antibodies | ELISA Kits |
Anti-KYNU Antibody (CAB6643) | Human Kynureninase ELISA Kit |
KYNU Antibody (PACO10179) | Human Kynureninase (KYNU) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |