UniProt Protein Function: | KREMEN1: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 22q12.1 Cellular Component: membrane; integral to membrane Molecular Function:protein binding Biological Process: Wnt receptor signaling pathway; cell communication |
NCBI Summary: | This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q96MU8 |
NCBI GenInfo Identifier: | 24041012 |
NCBI Gene ID: | 83999 |
NCBI Accession: | NP_114434 |
UniProt Secondary Accession: | Q96MU8,Q5TIB9, Q6P3X6, Q9BY70, Q9UGS5, Q9UGU1, B0QY46 B0QY47, B1AJR5, |
UniProt Related Accession: | Q96MU8 |
Molecular Weight: | 54 kDa |
NCBI Full Name: | kremen protein 1 isoform 2 |
NCBI Synonym Full Names: | kringle containing transmembrane protein 1 |
NCBI Official Symbol: | KREMEN1 |
NCBI Official Synonym Symbols: | KRM1; KREMEN |
NCBI Protein Information: | kremen protein 1; dickkopf receptor; kringle-coding gene marking the eye and the nose; kringle domain-containing transmembrane protein 1; kringle-containing protein marking the eye and the nose |
UniProt Protein Name: | Kremen protein 1 |
UniProt Synonym Protein Names: | Dickkopf receptor; Kringle domain-containing transmembrane protein 1; Kringle-containing protein marking the eye and the nose |
Protein Family: | Kremen protein |
UniProt Gene Name: | KREMEN1 |
UniProt Entry Name: | KREM1_HUMAN |