| UniProt Protein Function: | KLRG1: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12p13.31Cellular Component: plasma membrane; integral to membraneMolecular Function: receptor activity; carbohydrate bindingBiological Process: regulation of immune response; cell surface receptor linked signal transduction; innate immune response; cellular defense response; inflammatory response |
| UniProt Protein Details: | |
| NCBI Summary: | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96E93 |
| NCBI GenInfo Identifier: | 47717096 |
| NCBI Gene ID: | 10219 |
| NCBI Accession: | NP_005801.3 |
| UniProt Secondary Accession: | Q96E93,O43198, O75613, B7ZAM2 |
| UniProt Related Accession: | Q96E93 |
| Molecular Weight: | 21,206 Da |
| NCBI Full Name: | killer cell lectin-like receptor subfamily G member 1 |
| NCBI Synonym Full Names: | killer cell lectin-like receptor subfamily G, member 1 |
| NCBI Official Symbol: | KLRG1 |
| NCBI Official Synonym Symbols: | 2F1; MAFA; MAFA-L; CLEC15A; MAFA-2F1; MAFA-LIKE |
| NCBI Protein Information: | killer cell lectin-like receptor subfamily G member 1; MAFA-like receptor; ITIM-containing receptor MAFA-L; C-type lectin domain family 15 member A; C-type lectin domain family 15, member A; mast cell function-associated antigen (ITIM-containing) |
| UniProt Protein Name: | Killer cell lectin-like receptor subfamily G member 1 |
| UniProt Synonym Protein Names: | C-type lectin domain family 15 member A; ITIM-containing receptor MAFA-L; MAFA-like receptor; Mast cell function-associated antigen |
| Protein Family: | |
| UniProt Gene Name: | KLRG1 |
| UniProt Entry Name: | KLRG1_HUMAN |
