KAT8 Antibody (PACO50190)
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주문- SKU:
- PACO50190
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | KAT8 Antibody (PACO50190) |
Antibody SKU: | PACO50190 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Recombinant Human Histone acetyltransferase KAT8 protein (1-168AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: MCF-7 whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell ltysate, Mouse liver tissue, Rat liver tissue. All lanes: KAT8 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 53, 54 kDa. Observed band size: 53 kDa.. |
Background: | Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'. |
Synonyms: | Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF), KAT8, MOF MYST1 |
UniProt Protein Function: | MYST1: Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Belongs to the MYST (SAS/MOZ) family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.3.1.48; Acetyltransferase Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: kinetochore; nucleoplasm; nuclear membrane; nucleus; histone acetyltransferase complex Molecular Function:protein binding; histone acetyltransferase activity; enzyme binding; metal ion binding; acetyltransferase activity; histone acetyltransferase activity (H4-K16 specific); transcription factor binding; methylated histone residue binding Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; myeloid cell differentiation; regulation of autophagy; histone acetylation; negative regulation of transcription, DNA-dependent |
NCBI Summary: | This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q9H7Z6 |
NCBI GenInfo Identifier: | 68565938 |
NCBI Gene ID: | 84148 |
NCBI Accession: | Q9H7Z6.2 |
UniProt Related Accession: | Q9H7Z6 |
Molecular Weight: | |
NCBI Full Name: | Histone acetyltransferase KAT8 |
NCBI Synonym Full Names: | lysine acetyltransferase 8 |
NCBI Official Symbol: | KAT8 |
NCBI Official Synonym Symbols: | MOF; hMOF; MYST1; ZC2HC8 |
NCBI Protein Information: | histone acetyltransferase KAT8 |
UniProt Protein Name: | Histone acetyltransferase KAT8 |
UniProt Synonym Protein Names: | Lysine acetyltransferase 8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST-1; hMOF |
Protein Family: | Males-absent on the first protein |
UniProt Gene Name: | KAT8 |
UniProt Entry Name: | KAT8_HUMAN |
Antibodies | ELISA Kits |
Anti-MYST1 Antibody (CAB2208) | Human KAT8 / MYST1 / MOF ELISA Kit |
KAT8 Antibody (PACO05499) | Human Histone acetyltransferase KAT8 (KAT8) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |