JPH1 Antibody (PACO57492)
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주문- SKU:
- PACO57492
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | JPH1 Antibody (PACO57492) |
Antibody SKU: | PACO57492 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Junctophilin-1 protein (431-546AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO57492 diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. |
![]() | Immunofluorescence staining of Hela cells with PACO57492 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
Synonyms: | Junctophilin-1 (JP-1) (Junctophilin type 1), JPH1, JP1 |
UniProt Protein Function: | JPH1: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. Belongs to the junctophilin family. |
UniProt Protein Details: | Protein type:Endoplasmic reticulum; Membrane protein, integral Chromosomal Location of Human Ortholog: 8q21 Cellular Component: junctional membrane complex; plasma membrane; integral to membrane; Z disc Molecular Function:structural constituent of muscle Biological Process: muscle development |
NCBI Summary: | Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9HDC5 |
NCBI GenInfo Identifier: | 145337941 |
NCBI Gene ID: | 56704 |
NCBI Accession: | AAI39833 |
UniProt Secondary Accession: | Q9HDC5,B2RTZ0, |
UniProt Related Accession: | Q9HDC5 |
Molecular Weight: | 71,686 Da |
NCBI Full Name: | JPH1 protein, partial |
NCBI Synonym Full Names: | junctophilin 1 |
NCBI Official Symbol: | JPH1 |
NCBI Official Synonym Symbols: | JP1; JP-1 |
NCBI Protein Information: | junctophilin-1; mitsugumin72; junctophilin type1; junctophilin type 1 |
UniProt Protein Name: | Junctophilin-1 |
UniProt Synonym Protein Names: | Junctophilin type 1 |
Protein Family: | Junctophilin |
UniProt Gene Name: | JPH1 |
UniProt Entry Name: | JPH1_HUMAN |
Antibodies |
Anti-JPH1 Antibody (CAB18476) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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