IWS1 Antibody (PACO44645)
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주문- SKU:
- PACO44645
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IWS1 Antibody (PACO44645) |
Antibody SKU: | PACO44645 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Protein IWS1 homolog protein (570-819AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: IWS1 antibody at 3.84µg/ml. Lane 1: 293T whole cell lysate. Lane 2: Jurkat whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 92, 57, 70 kDa. Observed band size: 70 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human liver cancer using PACO44645 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human liver tissue using PACO44645 at dilution of 1:100. |
Background: | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. |
Synonyms: | Protein IWS1 homolog (IWS1-like protein), IWS1, IWS1L |
UniProt Protein Function: | IWS1: a Pol II transcription elongation factor essential for mammalian cell proliferation. Interacts with Spt6 and Spt5. Depletion of endogenous human IWS1 results in mRNA processing defects. Three alternatively spliced human isoforms have been described. |
UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 2q14.3 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:protein binding; DNA binding Biological Process: mRNA transport; regulation of transcription, DNA-dependent; transcription, DNA-dependent; RNA splicing; mRNA processing; regulation of mRNA processing |
UniProt Code: | Q96ST2 |
NCBI GenInfo Identifier: | 85542184 |
NCBI Gene ID: | 55677 |
NCBI Accession: | Q96ST2.2 |
UniProt Secondary Accession: | Q96ST2,Q2TB65, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8 |
UniProt Related Accession: | Q96ST2 |
Molecular Weight: | 819 |
NCBI Full Name: | Protein IWS1 homolog |
NCBI Synonym Full Names: | IWS1 homolog (S. cerevisiae) |
NCBI Official Symbol: | IWS1 |
NCBI Protein Information: | protein IWS1 homolog; IWS1-like protein; interacts with Spt6 |
UniProt Protein Name: | Protein IWS1 homolog |
UniProt Synonym Protein Names: | IWS1-like protein |
Protein Family: | IWS1-like protein |
UniProt Gene Name: | IWS1 |
UniProt Entry Name: | IWS1_HUMAN |