ITPR3 Antibody (PACO19865)
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주문- SKU:
- PACO19865
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ITPR3 Antibody (PACO19865) |
Antibody SKU: | PACO19865 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human ITPR3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19865(ITPR3 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19865(ITPR3 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. |
Synonyms: | inositol 1,4,5-trisphosphate receptor, type 3 |
UniProt Protein Function: | JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 20p12.1-p11.23 Cellular Component: membrane; apical part of cell; integral to plasma membrane; extracellular region; plasma membrane Molecular Function:protein binding; growth factor activity; calcium ion binding; structural molecule activity; Notch binding Biological Process: endothelial cell differentiation; nervous system development; Notch signaling pathway; positive regulation of myeloid cell differentiation; T cell mediated immunity; Notch receptor processing; auditory receptor cell differentiation; cell fate determination; negative regulation of fat cell differentiation; regulation of cell migration; regulation of cell proliferation; keratinocyte differentiation; myoblast differentiation; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; response to muramyl dipeptide; morphogenesis of an epithelial sheet; positive regulation of transcription from RNA polymerase II promoter; hemopoiesis; blood vessel remodeling; angiogenesis; positive regulation of Notch signaling pathway Disease: Tetralogy Of Fallot; Alagille Syndrome 1 |
NCBI Summary: | This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010] |
UniProt Code: | Q14573 |
NCBI GenInfo Identifier: | 153945846 |
NCBI Gene ID: | 3710 |
NCBI Accession: | NP_002215 |
UniProt Related Accession: | Q14573 |
Molecular Weight: | |
NCBI Full Name: | inositol 1,4,5-trisphosphate receptor type 3 |
NCBI Synonym Full Names: | inositol 1,4,5-trisphosphate receptor type 3 |
NCBI Official Symbol: | ITPR3 |
NCBI Official Synonym Symbols: | IP3R; IP3R3 |
NCBI Protein Information: | inositol 1,4,5-trisphosphate receptor type 3 |
UniProt Protein Name: | Protein jagged-1 |
UniProt Synonym Protein Names: | CD_antigen: CD339 |
Protein Family: | Protein jagged |
UniProt Gene Name: | JAG1 |
UniProt Entry Name: | JAG1_HUMAN |
Antibodies |
Anti-ITPR3 Antibody (CAB12794) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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