ITGB7 Antibody (PACO19853)
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주문- SKU:
- PACO19853
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ITGB7 Antibody (PACO19853) |
Antibody SKU: | PACO19853 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:100-1:300 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human ITGB7 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19853(ITGB7 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19853(ITGB7 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an α chain and a β chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. |
Synonyms: | integrin, β 7 |
UniProt Protein Function: | ITGB7: integrin alpha-4/beta-7 (Peyer's patches-specific homing receptor lpam-1) is expected to play a role in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM 1. Integrin alpha-e/beta-7 (HML-1) is a receptor for e-cadherin. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Receptor, misc.; Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: cell surface; membrane; plasma membrane; integrin complex; receptor complex Molecular Function:viral receptor activity; protein binding; metal ion binding; cell adhesion molecule binding Biological Process: integrin-mediated signaling pathway; heterotypic cell-cell adhesion; extracellular matrix organization and biogenesis; regulation of immune response; entry of virus into host cell; multicellular organismal development; cell-matrix adhesion; cell adhesion; leukocyte tethering or rolling; receptor clustering |
NCBI Summary: | This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013] |
UniProt Code: | P26010 |
NCBI GenInfo Identifier: | 124973 |
NCBI Gene ID: | 3695 |
NCBI Accession: | P26010.1 |
UniProt Secondary Accession: | P26010,Q9UCP7, Q9UCS7, |
UniProt Related Accession: | P26010 |
Molecular Weight: | 798 |
NCBI Full Name: | Integrin beta-7 |
NCBI Synonym Full Names: | integrin, beta 7 |
NCBI Official Symbol: | ITGB7 |
NCBI Protein Information: | integrin beta-7; integrin beta 7 subunit; gut homing receptor beta subunit |
UniProt Protein Name: | Integrin beta-7 |
UniProt Synonym Protein Names: | Gut homing receptor beta subunit |
Protein Family: | Integrin |
UniProt Gene Name: | ITGB7 |
UniProt Entry Name: | ITB7_HUMAN |