ITGB5 Antibody (PACO14591)
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주문- SKU:
- PACO14591
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ITGB5 Antibody (PACO14591) |
Antibody SKU: | PACO14591 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human ITGB5 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14591(ITGB5 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO14591(ITGB5 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. |
Synonyms: | integrin, β 5 |
UniProt Protein Function: | ITGB5: Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10. Belongs to the integrin beta chain family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 3q21.2 Cellular Component: cell surface; focal adhesion; phagocytic vesicle; plasma membrane; receptor complex Molecular Function:protein binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell-matrix adhesion; extracellular matrix organization and biogenesis; integrin-mediated signaling pathway; muscle contraction; stress fiber formation; transforming growth factor beta receptor signaling pathway |
UniProt Code: | P18084 |
NCBI GenInfo Identifier: | 124970 |
NCBI Gene ID: | 3693 |
NCBI Accession: | P18084.1 |
UniProt Secondary Accession: | P18084,B0LPF8, B2RD70, |
UniProt Related Accession: | P18084 |
Molecular Weight: | 88,054 Da |
NCBI Full Name: | Integrin beta-5 |
NCBI Synonym Full Names: | integrin subunit beta 5 |
NCBI Official Symbol: | ITGB5 |
NCBI Protein Information: | integrin beta-5 |
UniProt Protein Name: | Integrin beta-5 |
Protein Family: | Integrin |
UniProt Gene Name: | ITGB5 |
UniProt Entry Name: | ITB5_HUMAN |