ITGAE Antibody (PACO16553)
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주문- SKU:
- PACO16553
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ITGAE Antibody (PACO16553) |
Antibody SKU: | PACO16553 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human ITGAE |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO16553(ITGAE Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16553(ITGAE Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Integrins are heterodimeric integral membrane proteins composed of an α chain and a β chain. This gene encodes an I-domain-containing α integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the β 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. |
Synonyms: | integrin, α E (antigen CD103, human mucosal lymphocyte antigen 1; α polypeptide) |
UniProt Protein Function: | ITGAE: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Belongs to the integrin alpha chain family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral Chromosomal Location of Human Ortholog: 17p13 Cellular Component: plasma membrane; integrin complex; external side of plasma membrane Molecular Function:metal ion binding Biological Process: integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; cell adhesion |
NCBI Summary: | Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008] |
UniProt Code: | P38570 |
NCBI GenInfo Identifier: | 226694184 |
NCBI Gene ID: | 3682 |
NCBI Accession: | P38570.3 |
UniProt Secondary Accession: | P38570,Q17RS6, Q9NZU9, |
UniProt Related Accession: | P38570 |
Molecular Weight: | 130,159 Da |
NCBI Full Name: | Integrin alpha-E |
NCBI Synonym Full Names: | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
NCBI Official Symbol: | ITGAE |
NCBI Official Synonym Symbols: | CD103; HUMINAE |
NCBI Protein Information: | integrin alpha-E; HML-1 antigen; integrin alpha-IEL; mucosal lymphocyte 1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide |
UniProt Protein Name: | Integrin alpha-E |
UniProt Synonym Protein Names: | HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD_antigen: CD103Cleaved into the following 2 chains:Integrin alpha-E light chain; Integrin alpha-E heavy chain |
Protein Family: | Integrin |
UniProt Gene Name: | ITGAE |
UniProt Entry Name: | ITAE_HUMAN |