ITGA2B Antibody (PACO16550)
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주문- SKU:
- PACO16550
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ITGA2B Antibody (PACO16550) |
Antibody SKU: | PACO16550 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human ITGA2B |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO16550(ITGA2B Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal liver tissue, Human placenta tissue, Primary antibody: PACO16550(ITGA2B Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16550(ITGA2B Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | ITGA2B encodes integrin α chain 2b. Integrins are heterodimeric integral membrane proteins composed of an α chain and a β chain. α chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with β 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. |
Synonyms: | integrin, α 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
UniProt Protein Function: | ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q21.31 Cellular Component: cell surface; integral to plasma membrane; plasma membrane; platelet alpha granule membrane Molecular Function:identical protein binding; protein binding Biological Process: cell adhesion; extracellular matrix organization and biogenesis; integrin-mediated signaling pathway; platelet degranulation Disease: Bleeding Disorder, Platelet-type, 16; Glanzmann Thrombasthenia |
NCBI Summary: | This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016] |
UniProt Code: | P08514 |
NCBI GenInfo Identifier: | 226694183 |
NCBI Gene ID: | 3674 |
NCBI Accession: | P08514.3 |
UniProt Secondary Accession: | P08514,O95366, Q14443, Q17R67, B2RCY8, |
UniProt Related Accession: | P08514 |
Molecular Weight: | 113kDa |
NCBI Full Name: | Integrin alpha-IIb |
NCBI Synonym Full Names: | integrin subunit alpha 2b |
NCBI Official Symbol: | ITGA2B |
NCBI Official Synonym Symbols: | GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93 |
NCBI Protein Information: | integrin alpha-IIb |
UniProt Protein Name: | Integrin alpha-IIb |
UniProt Synonym Protein Names: | GPalpha IIb; GPIIb |
Protein Family: | Integrin |
UniProt Gene Name: | ITGA2B |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |