ITGA2 Antibody (PACO18586)
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주문- SKU:
- PACO18586
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ITGA2 Antibody (PACO18586) |
Antibody SKU: | PACO18586 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human ITGA2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18586(ITGA2 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human lung cancer tissue, A431 cells, Primary antibody: PACO18586(ITGA2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO18586(ITGA2 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes the α subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a β subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related α subunit gene. Alternative splicing results in multiple transcript variants. |
Synonyms: | integrin, α 2 (CD49B, α 2 subunit of VLA-2 receptor) |
UniProt Protein Function: | ITGA2: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Belongs to the integrin alpha chain family. |
UniProt Protein Details: | Protein type:Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 5q11.2 Cellular Component: cell surface; focal adhesion; integrin complex; plasma membrane Molecular Function:collagen binding; protein binding; protein complex binding Biological Process: blood coagulation; cell adhesion; cell adhesion mediated by integrin; cell-matrix adhesion; cell-substrate adhesion; extracellular matrix organization and biogenesis; integrin-mediated signaling pathway; mesodermal cell differentiation; organ morphogenesis; substrate-bound cell migration Disease: Bleeding Disorder, Platelet-type, 9 |
NCBI Summary: | This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
UniProt Code: | P17301 |
NCBI GenInfo Identifier: | 124942 |
NCBI Gene ID: | 3673 |
NCBI Accession: | P17301.1 |
UniProt Secondary Accession: | P17301,Q14595, |
UniProt Related Accession: | P17301 |
Molecular Weight: | 129,295 Da |
NCBI Full Name: | Integrin alpha-2 |
NCBI Synonym Full Names: | integrin subunit alpha 2 |
NCBI Official Symbol: | ITGA2 |
NCBI Official Synonym Symbols: | BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2 |
NCBI Protein Information: | integrin alpha-2 |
UniProt Protein Name: | Integrin alpha-2 |
UniProt Synonym Protein Names: | CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD_antigen: CD49b |
Protein Family: | Integrin |
UniProt Gene Name: | ITGA2 |
UniProt Entry Name: | ITA2_HUMAN |
Antibodies |
Anti-ITGA2 Antibody (CAB7629)[KO Validated] |
Anti-Integrin alpha 2 Antibody (CAB19068) |
ITGA2 Antibody (PACO06887) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |