IRAK3 Antibody (PACO43035)
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주문- SKU:
- PACO43035
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | IRAK3 Antibody (PACO43035) |
Antibody SKU: | PACO43035 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA |
Recommended Dilutions: | |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Interleukin-1 receptor-associated kinase 3 protein (367-596AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Background: | Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. |
Synonyms: | Interleukin-1 receptor-associated kinase 3 (IRAK-3) (EC 2.7.11.1) (IL-1 receptor-associated kinase M) (IRAK-M), IRAK3 |
UniProt Protein Function: | IRAK3: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs. |
UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.1; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; IRAK family Chromosomal Location of Human Ortholog: 12q14.3 Cellular Component: interleukin-1 receptor complex; cytoplasm; nucleus Molecular Function:protein serine/threonine kinase activity; protein homodimerization activity; protein heterodimerization activity; magnesium ion binding; ATP binding Biological Process: negative regulation of MAP kinase activity; negative regulation of interleukin-12 production; regulation of protein complex disassembly; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; response to virus; response to lipopolysaccharide; negative regulation of tumor necrosis factor production; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; MyD88-dependent toll-like receptor signaling pathway; response to exogenous dsRNA; negative regulation of innate immune response; inhibition of NF-kappaB transcription factor; response to peptidoglycan; negative regulation of toll-like receptor signaling pathway; negative regulation of interleukin-6 production; toll-like receptor signaling pathway; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of protein catabolic process; negative regulation of protein complex disassembly Disease: Asthma-related Traits, Susceptibility To, 5 |
NCBI Summary: | This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
UniProt Code: | Q9Y616 |
NCBI GenInfo Identifier: | 322510038 |
NCBI Gene ID: | 11213 |
NCBI Accession: | Q9Y616.2 |
UniProt Secondary Accession: | Q9Y616,B4DQ57, |
UniProt Related Accession: | Q9Y616 |
Molecular Weight: | 596 |
NCBI Full Name: | Interleukin-1 receptor-associated kinase 3 |
NCBI Synonym Full Names: | interleukin-1 receptor-associated kinase 3 |
NCBI Official Symbol: | IRAK3 |
NCBI Official Synonym Symbols: | ASRT5; IRAKM |
NCBI Protein Information: | interleukin-1 receptor-associated kinase 3; IRAK3; IL-1 receptor-associated kinase M |
UniProt Protein Name: | Interleukin-1 receptor-associated kinase 3 |
UniProt Synonym Protein Names: | IL-1 receptor-associated kinase M; IRAK-M |
Protein Family: | Interleukin-1 receptor-associated kinase |
UniProt Gene Name: | IRAK3 |
UniProt Entry Name: | IRAK3_HUMAN |