IPO9 Antibody (PACO19843)
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주문- SKU:
- PACO19843
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IPO9 Antibody (PACO19843) |
Antibody SKU: | PACO19843 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human IPO9 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19843(IPO9 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal brain tissue, Hela cells, Primary antibody: PACO19843(IPO9 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19843(IPO9 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Importin-9, also known as Imp9 or IPO9, is a 1,041 amino acid, protein that contains one importin N-terminal domain and belongs to the Importin-∫ family. Localized to both the nucleus and the cytoplasm, Importin-9 functions as a nuclear transport receptor that mediates the docking of the Importin complex to the nuclear pore complex (NPC). Importin-9 mediates nuclear import of H2B histone, Ribosomal Protein S7 and Ribosomal Protein L18A. The gene encoding Importin-9 is located on human chromosome 1, the largest human chromosome that spans about 260 million base pairs and makes up 8% of the human genome. |
Synonyms: | importin 9 |
UniProt Protein Function: | IPO9: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of H2B histone, RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones, RPL4 and RPL6. Belongs to the importin beta family. |
UniProt Protein Details: | Protein type:Karyopherin; Nuclear import Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: cytoplasm; membrane Molecular Function:histone binding; protein binding; protein transporter activity |
UniProt Code: | Q96P70 |
NCBI GenInfo Identifier: | 41688593 |
NCBI Gene ID: | 55705 |
NCBI Accession: | Q96P70.3 |
UniProt Secondary Accession: | Q96P70,Q8N1Y1, Q8N3I2, Q8NCG9, Q96SU6, Q9NW01, Q9P0A8 Q9ULM8, B1ASV5, |
UniProt Related Accession: | Q96P70 |
Molecular Weight: | 116kDa |
NCBI Full Name: | Importin-9 |
NCBI Synonym Full Names: | importin 9 |
NCBI Official Symbol: | IPO9 |
NCBI Official Synonym Symbols: | Imp9 |
NCBI Protein Information: | importin-9 |
UniProt Protein Name: | Importin-9 |
UniProt Synonym Protein Names: | Ran-binding protein 9; RanBP9 |
Protein Family: | Importin |
UniProt Gene Name: | IPO9 |