INTS6 Antibody (PACO56852)
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주문- SKU:
- PACO56852
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | INTS6 Antibody (PACO56852) |
Antibody SKU: | PACO56852 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Integrator complex subunit 6 protein (571-795AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunofluorescence staining of A549 cells with PACO56852 at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth. |
Synonyms: | Integrator complex subunit 6 (Int6) (DBI-1) (Protein DDX26) (Protein deleted in cancer 1) (DICE1), INTS6, DBI1 DDX26 DDX26A |
UniProt Protein Function: | INTS6: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth. Belongs to the Integrator subunit 6 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:RNA processing; Receptor, misc. Chromosomal Location of Human Ortholog: 13q14.3 Cellular Component: nucleoplasm; integrator complex; actin cytoskeleton Molecular Function:protein binding; transmembrane receptor activity Biological Process: snRNA processing; signal transduction |
NCBI Summary: | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UL03 |
NCBI GenInfo Identifier: | 74753376 |
NCBI Gene ID: | 26512 |
NCBI Accession: | Q9UL03.1 |
UniProt Secondary Accession: | Q9UL03,Q0P664, Q6PJP4, Q9UFK0, Q9Y5M9, |
UniProt Related Accession: | Q9UL03 |
Molecular Weight: | 887 |
NCBI Full Name: | Integrator complex subunit 6 |
NCBI Synonym Full Names: | integrator complex subunit 6 |
NCBI Official Symbol: | INTS6 |
NCBI Official Synonym Symbols: | HDB; INT6; DBI-1; DDX26; DICE1; DDX26A; Notchl2 |
NCBI Protein Information: | integrator complex subunit 6; DEAD box protein; RNA helicase HDB; protein deleted in cancer 1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 |
UniProt Protein Name: | Integrator complex subunit 6 |
UniProt Synonym Protein Names: | DBI-1; Protein DDX26; Protein deleted in cancer 1; DICE1 |
Protein Family: | Integrator complex |
UniProt Gene Name: | INTS6 |
UniProt Entry Name: | INT6_HUMAN |
Antibodies |
Anti-INTS6 Antibody (CAB6634) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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