UniProt Protein Function: | ID3: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-3 inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors. Induced by phorbol 12-myristate 13-acetate (PMA). Interacts with COPS5 and COPS7A. Homodimer, and heterodimer with other HLH proteins. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; DNA-binding Chromosomal Location of Human Ortholog: 1p36.13-p36.12 Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus Molecular Function:protein binding; transcription corepressor activity Biological Process: multicellular organismal development; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent |
NCBI Summary: | The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q02535 |
NCBI GenInfo Identifier: | 322510035 |
NCBI Gene ID: | 3399 |
NCBI Accession: | Q02535.2 |
UniProt Secondary Accession: | Q02535,O75641, A8K1T8, |
UniProt Related Accession: | Q02535 |
Molecular Weight: | 12,999 Da |
NCBI Full Name: | DNA-binding protein inhibitor ID-3 |
NCBI Synonym Full Names: | inhibitor of DNA binding 3, HLH protein |
NCBI Official Symbol: | ID3 |
NCBI Official Synonym Symbols: | HEIR-1; bHLHb25 |
NCBI Protein Information: | DNA-binding protein inhibitor ID-3 |
UniProt Protein Name: | DNA-binding protein inhibitor ID-3 |
UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 25; bHLHb25; Helix-loop-helix protein HEIR-1; ID-like protein inhibitor HLH 1R21; Inhibitor of DNA binding 3; Inhibitor of differentiation 3 |
Protein Family: | DNA-binding protein inhibitor |
UniProt Gene Name: | ID3 |
UniProt Entry Name: | ID3_HUMAN |