ICOS Antibody (PACO14549)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO14549
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ICOS Antibody (PACO14549) |
Antibody SKU: | PACO14549 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:20-1:100 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human ICOS |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO14549(ICOS Antibody) at dilution 1/17, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. |
Synonyms: | inducible T-cell co-stimulator |
UniProt Protein Function: | ICOS: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1). CVID1 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be lo. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 2q33 Cellular Component: integral to plasma membrane; extracellular region; plasma membrane; external side of plasma membrane Biological Process: cell-cell adhesion; T cell tolerance induction; T cell costimulation; immune response Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 1 |
NCBI Summary: | The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y6W8 |
NCBI GenInfo Identifier: | 50400701 |
NCBI Gene ID: | 29851 |
NCBI Accession: | Q9Y6W8.1 |
UniProt Secondary Accession: | Q9Y6W8,Q8N6W8, |
UniProt Related Accession: | Q9Y6W8 |
Molecular Weight: | 199 |
NCBI Full Name: | Inducible T-cell costimulator |
NCBI Synonym Full Names: | inducible T-cell co-stimulator |
NCBI Official Symbol: | ICOS |
NCBI Official Synonym Symbols: | AILIM; CD278; CVID1 |
NCBI Protein Information: | inducible T-cell costimulator; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule |
UniProt Protein Name: | Inducible T-cell costimulator |
UniProt Synonym Protein Names: | Activation-inducible lymphocyte immunomediatory molecule; CD_antigen: CD278 |
Protein Family: | ICOS ligand |
UniProt Gene Name: | ICOS |
UniProt Entry Name: | ICOS_HUMAN |
Antibodies | ELISA Kits |
Anti-ICOS Antibody (CAB1811) | Human ICOS (Inducible T-cell costimulator) ELISA Kit (HUFI05146) |
Anti-ICOS Antibody (CAB5130) | |
ICOS Antibody (PACO07225) | |
ICOS Antibody (PACO09858) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |