IBSP Antibody (PACO19361)
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주문- SKU:
- PACO19361
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IBSP Antibody (PACO19361) |
Antibody SKU: | PACO19361 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human IBSP |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19361(IBSP Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela cells, K562 cells, hepG2 cells, Primary antibody: PACO19361(IBSP Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19361(IBSP Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acid, c amino acid, clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. |
Synonyms: | integrin-binding sialoprotein |
UniProt Protein Function: | Sialoprotein-2: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 4q21.1 Cellular Component: extracellular space; membrane; extracellular region Biological Process: osteoblast differentiation; extracellular matrix organization and biogenesis; biomineral formation; cell adhesion |
NCBI Summary: | The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008] |
UniProt Code: | P21815 |
NCBI GenInfo Identifier: | 317373545 |
NCBI Gene ID: | 3381 |
NCBI Accession: | P21815.4 |
UniProt Related Accession: | P21815 |
Molecular Weight: | 35,148 Da |
NCBI Full Name: | Bone sialoprotein 2 |
NCBI Synonym Full Names: | integrin-binding sialoprotein |
NCBI Official Symbol: | IBSP |
NCBI Official Synonym Symbols: | BSP; BNSP; SP-II; BSP-II |
NCBI Protein Information: | bone sialoprotein 2; BSP II; bone sialoprotein II; cell-binding sialoprotein |
UniProt Protein Name: | Bone sialoprotein 2 |
UniProt Synonym Protein Names: | Bone sialoprotein II; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein |
Protein Family: | Bone sialoprotein |
UniProt Gene Name: | IBSP |
UniProt Entry Name: | SIAL_HUMAN |
Antibodies | ELISA Kits |
Anti-IBSP Antibody (CAB16220) | Human BSP (Bone Sialoprotein) CLIA Kit (HUES00397) |
Human BSP (Bone Sialoprotein) ELISA Kit (HUES01764) | |
Human Bone sialoprotein 2 (IBSP) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |