Human ZWILCH Recombinant Protein (RPPB5190)

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SKU:
RPPB5190
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
ZWILCH
Synonyms:
hZwilch
Synonyms:
KNTC1AP
Synonyms:
Protein zwilch homolog
Synonyms:
ZWILCH
Source:
Escherichia Coli
Uniprot:
Q9H900
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Description

Product Name:Human ZWILCH Recombinant Protein
Product Code:RPPB5190
Size:10µg
Species:Human
Target:ZWILCH
Synonyms:hZwilch, KNTC1AP, Protein zwilch homolog, ZWILCH.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:ZWILCH protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMWERLNC AAEDFYSRLL QKFNEEKKGI RKDPFLYEAD VQVQLISKGQ PNPLKNILNE NDIVFIVEKV PLEKEETSHI EELQSEETAI SDFSTGENVG PLALPVGKAR QLIGLYTMAH NPNMTHLKIN LPVTALPPLW VRCDSSDPEG TCWLGAELIT TNNSITGIVL YVVSCKADKN YSVNLENLKN LHKKRHHLST VTSKGFAQYE LFKSSALDDT ITASQTAIAL DISWSPVDEI LQIPPLSSTA TLNIKVESGE PRGPLNHLYR ELKFLLVLAD GLRTGVTEWL EPLEAKSAVE LVQEFLNDLN KLDGFGDSTK KDTEVETLKH DTAAVDRSVK RLFKVRSDLD FAEQLWCKMS SSVISYQDLV KCFTLIIQSL QRGDIQPWLH SGSNSLLSKL IHQSYHGTMD TVSLSGTIPV QMLLEIGLDK LKKDYISFFI GQELASLNHL EYFIAPSVDI QEQVYRVQKL HHILEILVSC MPFIKSQHEL LFSLTQICIK YYKQNPLDEQ HIFQLPVRPT AVKNLYQSEK PQKWRVEIYS GQKKIKTVWQ LSDSSPIDHL NFHKPDFSEL TLNGSLEERI FFTNMVTCSQ VHFK

Zwilch Kinetochore Protein which is also known as ZWILCH is a part of the ZWILCH family. ZWILCH is a vital part of the mitotic checkpoint. ZWILCH prevents the cells from exiting mitosis prematurely. ZWILCH is also necessary for the assembly of the dyneindynactin and MAD1-MAD2 complexes onto kinetochores.

ZWILCH Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 614 amino acids (1-591 a.a) and having a molecular mass of 69.6kDa. ZWILCH is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ZWILCH: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Belongs to the ZWILCH family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: cytosol; kinetochore

Molecular Function:protein binding

Biological Process: mitotic cell cycle checkpoint; sister chromatid cohesion

UniProt Code:Q9H900
NCBI GenInfo Identifier:166228729
NCBI Gene ID:55055
NCBI Accession:Q9H900.2
UniProt Secondary Accession:Q9H900,Q6N049, Q8N404, Q96SY7, Q9NWG7, B3KVB8,
UniProt Related Accession:Q9H900
Molecular Weight:54,224 Da
NCBI Full Name:Protein zwilch homolog
NCBI Synonym Full Names:zwilch kinetochore protein
NCBI Official Symbol:ZWILCH  
NCBI Official Synonym Symbols:KNTC1AP; hZwilch  
NCBI Protein Information:protein zwilch homolog
UniProt Protein Name:Protein zwilch homolog
Protein Family:Protein zwilch
UniProt Gene Name:ZWILCH  
UniProt Entry Name:ZWILC_HUMAN
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