Human WLS Recombinant Protein (RPPB5152)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문
SKU:
RPPB5152
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
WLS
Synonyms:
C1orf139
Synonyms:
EVI
Synonyms:
GPR177
Synonyms:
MRP
Source:
Escherichia Coli
Uniprot:
Q5T9L3
€0.00
Frequently bought together:

Description

Product Name:Human WLS Recombinant Protein
Product Code:RPPB5152
Size:10µg
Species:Human
Target:WLS
Synonyms:C1orf139, EVI, GPR177, MRP, Protein wntless homolog, Integral membrane protein GPR177, Protein evenness interrupted homolog, Putative NF-kappa-B-activating protein 373, WLS.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:WLS protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0),0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMEMSPWF QFMLFILQLD IAFKLNNQIR ENAEVSMDVS LAYRDDAFAE WTEMAHERVP RKLKCTFTSP KTPEHEGRYY ECDVLPFMEI GSVAHKFYLL NIRLPVNEKK KINVGIGEIK DIRLVGIHQN GGFTK

WLS (Wnt trafficking regulator) is a multipass transmembrane protein which regulates the sorting and secretion of Wnt protein. WLS is necessitated for organogenesis during embryogenesis and for the establishment of the anterior-posterior axis. WLS is encoded by a gene which maps to human chromosome 1 and is expressed as multiple alternatively spliced isoforms. WLS promotes various cancers such as glioma tumourigenesis.

WLS Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids (101-232a.a) and having a molecular mass of 17.8kDa. WLS is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development.
UniProt Code:Q5T9L3
NCBI GenInfo Identifier:301069320
NCBI Gene ID:79971
NCBI Accession:NP_001002292.3
UniProt Secondary Accession:Q5T9L3,Q5JRS7, Q7Z2Z9, Q8NC43, B2RNT2,
UniProt Related Accession:Q5T9L3
Molecular Weight:62 kDa
NCBI Full Name:protein wntless homolog isoform 2
NCBI Synonym Full Names:Wnt ligand secretion mediator
NCBI Official Symbol:WLS  
NCBI Official Synonym Symbols:EVI; MRP; GPR177; mig-14; C1orf139  
NCBI Protein Information:protein wntless homolog
UniProt Protein Name:Protein wntless homolog
UniProt Synonym Protein Names:Integral membrane protein GPR177; Protein evenness interrupted homolog; EVI; Putative NF-kappa-B-activating protein 373
Protein Family:Protein wntless
UniProt Gene Name:WLS  
View AllClose

Related Products