Human VOPP1 Recombinant Protein (RPPB5127)

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SKU:
RPPB5127
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
VOPP1
Synonyms:
Vesicular overexpressed in cancer prosurvival protein 1
Synonyms:
EGFR-coamplified and overexpressed protein
Synonyms:
ECop
Synonyms:
Glioblastoma-amplified secreted protein
Source:
Escherichia Coli
Uniprot:
Q96AW1
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Description

Product Name:Human VOPP1 Recombinant Protein
Product Code:RPPB5127
Size:10µg
Species:Human
Target:VOPP1
Synonyms:Vesicular overexpressed in cancer prosurvival protein 1, EGFR-coamplified and overexpressed protein, ECop, Glioblastoma-amplified secreted protein, Putative NF-kappa-B-activating protein 055N, VOPP1, ECOP, GASP, FLJ20532, DKFZp564K0822.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The VOPP1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 30% glycerol and 0.2M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MRRRMYPPPL IEEPAFNVSY TRQPPNPGPG AQQPGPPYYT DPGGPGMNPV GNSMAMAFQV PPNSPQGSVA CPPPPAYCNT PPPPYEQVVK AK

Vesicular overexpressed in cancer prosurvival protein 1 (VOPP1) has been previously shown to be over-expressed in human glioblastoma multiform and squamous cell carcinoma. VOPP1 is a crucial regulator of NF-kappaB signaling, and this high-level, amplification-mediated VOPP1 expression, such as that occurring in tumors with amplified EGFR, might impact the resistance to apoptosis.

VOPP1 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 112 amino acids (82-172 a.a.) and having a molecular mass of 12kDa. The VOPP1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:ECOP: Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed. Belongs to the VOPP1/ECOP family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 7p11.2Cellular Component: cytoplasmic vesicle membrane; endosomeMolecular Function: signal transducer activity
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q96AW1
NCBI GenInfo Identifier:74760714
NCBI Gene ID:81552
NCBI Accession:Q96AW1.1
UniProt Secondary Accession:Q96AW1,Q6FIE3, Q8NBN8, Q96RE5, Q9H0W4, B0AZU1, B2RAT4 B3KS72, C9JWR3
UniProt Related Accession:Q96AW1
Molecular Weight:17,381 Da
NCBI Full Name:Vesicular, overexpressed in cancer, prosurvival protein 1
NCBI Synonym Full Names:vesicular, overexpressed in cancer, prosurvival protein 1
NCBI Official Symbol:VOPP1  
NCBI Official Synonym Symbols:ECOP; GASP  
NCBI Protein Information:vesicular, overexpressed in cancer, prosurvival protein 1
UniProt Protein Name:Vesicular, overexpressed in cancer, prosurvival protein 1
UniProt Synonym Protein Names:EGFR-coamplified and overexpressed protein; ECop; Glioblastoma-amplified secreted protein; Putative NF-kappa-B-activating protein 055N
Protein Family:Vesicular, overexpressed in cancer, prosurvival protein
UniProt Gene Name:VOPP1  
UniProt Entry Name:VOPP1_HUMAN
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