Human VAT1 Recombinant Protein (RPPB5113)

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SKU:
RPPB5113
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
VAT1
Synonyms:
Synaptic vesicle membrane protein VAT-1 homolog
Synonyms:
VAT1
Synonyms:
VATI
Source:
Escherichia Coli
Uniprot:
Q99536
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Description

Product Name:Human VAT1 Recombinant Protein
Product Code:RPPB5113
Size:10µg
Species:Human
Target:VAT1
Synonyms:Synaptic vesicle membrane protein VAT-1 homolog, VAT1, VATI.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:VAT1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 100mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSDEREVAEA ATGEDASSPP PKTEAASDPQ HPAASEGAAA AAASPPLLRC LVLTGFGGYD KVKLQSRPAA PPAPGPGQLT LRLRACGLNF ADLMARQGLY DRLPPLPVTP GMEGAGVVIA VGEGVSDRKA GDRVMVLNRS GMWQEEVTVP SVQTFLIPEA  MTFEEAAALL VNYITAYMVL FDFGNLQPGH SVLVHMAAGG VGMAAVQLCR TVENVTVFGT ASASKHEALK ENGVTHPIDY HTTDYVDEIK KISPKGVDIV MDPLGGSDTA KGYNLLKPMG KVVTYGMANL LTGPKRNLMA LARTWWNQFS VTALQLLQAN RAVCGFHLGY LDGEVELVSG VVARLLALYN QGHIKPHIDS VWPFEKVADA MKQMQEKKNV GKVLLVPGPE KEN

Synaptic vesicle membrane protein VAT-1 homolog (VAT1) is a member of the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. Synaptic vesicles are in charge of regulating the storage and release of neurotransmitters in the nerve terminal. VAT1 has an increased calcium ion-dependent expression in glioblastomas and on wounding, in basal keratinocytes. VAT1 is an abundant integral membrane protein of cholinergic synaptic vesicles and is believed to be involved in vesicular transport.

VAT1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 413 amino acids (1-393 a.a.) and having a molecular mass of 44.1kDa. VAT1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Possesses ATPase activity. Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2).
NCBI Summary:Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq, Jul 2008]
UniProt Code:Q99536
NCBI GenInfo Identifier:119581322
NCBI Gene ID:10493
NCBI Accession:EAW60918.1
UniProt Secondary Accession:Q99536,Q13035, Q5BKZ7, Q96A39, Q9BUT8, A8K345, B0AZP7 B4DPX4,
UniProt Related Accession:Q99536
Molecular Weight:28,341 Da
NCBI Full Name:vesicle amine transport protein 1 homolog (T californica), isoform CRA_a
NCBI Synonym Full Names:vesicle amine transport 1
NCBI Official Symbol:VAT1  
NCBI Official Synonym Symbols:VATI  
NCBI Protein Information:synaptic vesicle membrane protein VAT-1 homolog
UniProt Protein Name:Synaptic vesicle membrane protein VAT-1 homolog
Protein Family:Synaptic vesicle membrane protein
UniProt Gene Name:VAT1  
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