Human UXT Recombinant Protein (RPPB5099)
- SKU:
- RPPB5099
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- UXT
- Synonyms:
- Protein UXT
- Androgen receptor trapped clone 27 protein
- ART-27
- Ubiquitously expressed transcript protein
- Source:
- Escherichia Coli
- Uniprot:
- Q9UBK9
Description
| Product Name: | Human UXT Recombinant Protein |
| Product Code: | RPPB5099 |
| Size: | 20µg |
| Species: | Human |
| Target: | UXT |
| Synonyms: | Protein UXT, Androgen receptor trapped clone 27 protein, ART-27, Ubiquitously expressed transcript protein, UXT, HSPC024, STAP1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | UXT protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MATPPKRRAV EATGEKVLRY ETFISDVLQR DLRKVLDHRD KVYEQLAKYL QLRNVIERLQ EAKHSELYMQ VDLGCNFFVD TVVPDTSRIY VALGYGFFLE LTLAEALKFI DRKSSLLTEL SNSLTKDSMN IKAHIHMLLE GLRELQGLQN FPEKPHH |
Ubiquitously-expressed transcript (UXT) is a member of the UXT family. UXT serves as a cofactor which modulates androgen receptor-dependent transcription, and also has a crucial role in tumor necrosis factor-induced apoptosis. UXT gene expression has a role in tumorigenesis. UXT is ubiquitous expressed: it is expressed in prostate epithelial cells, overexpressed in a number of tumor tissues. The highest levels are found in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus.
UXT Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 177 amino acids (1-157 a.a.) and having a molecular mass of 20.4kDa.UXT is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | UXT: Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region. Belongs to the UXT family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: Xp11.23-p11.22 Cellular Component: centrosome; cytoskeleton; cytoplasm; nucleus; gamma-tubulin complex Molecular Function:actin filament binding; protein binding; microtubule binding; beta-tubulin binding; chromatin binding Biological Process: transcription, DNA-dependent; centrosome organization and biogenesis; negative regulation of transcription from RNA polymerase II promoter; microtubule cytoskeleton organization and biogenesis; mitochondrion transport along microtubule |
| NCBI Summary: | The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9UBK9 |
| NCBI GenInfo Identifier: | 8928445 |
| NCBI Gene ID: | 8409 |
| NCBI Accession: | Q9UBK9.1 |
| UniProt Secondary Accession: | Q9UBK9,Q5JZG3, Q9Y6E5, B2R561, |
| UniProt Related Accession: | Q9UBK9 |
| Molecular Weight: | 157 |
| NCBI Full Name: | Protein UXT |
| NCBI Synonym Full Names: | ubiquitously-expressed, prefoldin-like chaperone |
| NCBI Official Symbol: | UXT |
| NCBI Official Synonym Symbols: | STAP1; ART-27 |
| NCBI Protein Information: | protein UXT; SKP2-associated alpha PFD 1; ubiquitously expressed transcript protein; androgen receptor trapped clone 27 protein |
| UniProt Protein Name: | Protein UXT |
| UniProt Synonym Protein Names: | Androgen receptor trapped clone 27 protein; ART-27; Ubiquitously expressed transcript protein |
| Protein Family: | Protein |
| UniProt Gene Name: | UXT |
| UniProt Entry Name: | UXT_HUMAN |
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