Human UPRT Recombinant Protein (RPPB2410)

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SKU:
RPPB2410
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
UPRT
Synonyms:
Uracil phosphoribosyltransferase homolog
Synonyms:
Uracil phosphoribosyltransferase (FUR1) homolog (Scerevisiae)
Synonyms:
FUR1
Synonyms:
Uracil Phosphoribosyltransferase
Source:
Escherichia Coli
Uniprot:
Q96BW1
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Description

Product Name:Human UPRT Recombinant Protein
Product Code:RPPB2410
Size:10µg
Species:Human
Target:UPRT
Synonyms:Uracil phosphoribosyltransferase homolog, Uracil phosphoribosyltransferase (FUR1) homolog (S.cerevisiae), FUR1, Uracil Phosphoribosyltransferase, RP11-311P8.3, UPP, UPRT, UPRTase, UMP pyrophosphorylase, uprt.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:UPRT protein solution (0. 5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMATELQC PDSMPCHNQQ VNSASTPSPE QLRPGDLILD HAGGNRASRA KVILLTGYAH SSLPAELDSG ACGGSSLNSE GNSGSGDSSS YDAPAGNSFL EDCELSRQIG AQLKLLPMND QIRELQTIIR DKTASRGDFM FSADRLIRLV VEEGLNQLPY KECMVTTPTG YKYEGVKFEK GNCGVSIMRS GEAMEQGLRD CCRSIRIGKI LIQSDEETQR AKVYYAKFPP DIYRRKVLLM YPILSTGNTV IEAVKVLIEH GVQPSVIILL SLFSTPHGAK SIIQEFPEIT ILTTEVHPVA PTHFGQKYFG TD

UPRT is a uracil phosphoribosyltransferase, that catalyzes the alteration of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is a significant part of nucleotide metabolism, specifically the pyrimidine salvage pathway. UPRT is restricted to the nucleus and cytoplasm and is a possible target for rational design of drugs to cure cancer and parasitic infections.

UPRT Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 332 amino acids (1-309 a.a) and having a molecular mass of 36.2kDa.UPRT is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:UPRT: an enzyme which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]Protein type: EC 2.4.2.9; Transferase; Nucleotide Metabolism - pyrimidineChromosomal Location of Human Ortholog: Xq13.3Cellular Component: cytosolMolecular Function: protein binding; uridine kinase activityBiological Process: pyrimidine base metabolic process; pyrimidine nucleoside salvage
UniProt Protein Details:
NCBI Summary:This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]
UniProt Code:Q96BW1
NCBI GenInfo Identifier:74751783
NCBI Gene ID:139596
NCBI Accession:Q96BW1.1
UniProt Secondary Accession:Q96BW1,Q5JRL1, Q5JRL3, Q68DN0, Q96MW2
UniProt Related Accession:Q96BW1
Molecular Weight:19,056 Da
NCBI Full Name:Uracil phosphoribosyltransferase homolog
NCBI Synonym Full Names:uracil phosphoribosyltransferase homolog
NCBI Official Symbol:UPRT  
NCBI Official Synonym Symbols:UPP; FUR1  
NCBI Protein Information:uracil phosphoribosyltransferase homolog
UniProt Protein Name:Uracil phosphoribosyltransferase homolog
UniProt Synonym Protein Names:
Protein Family:Uracil phosphoribosyltransferase
UniProt Gene Name:UPRT  
UniProt Entry Name:UPP_HUMAN
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