Human UFM1 Recombinant Protein (RPPB5079)

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SKU:
RPPB5079
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
UFM1
Synonyms:
Ubiquitin-fold modifier 1
Synonyms:
UFM1
Synonyms:
C13orf20
Synonyms:
BM-002
Source:
Escherichia Coli
Uniprot:
P61960
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Description

Product Name:Human UFM1 Recombinant Protein
Product Code:RPPB5079
Size:20µg
Species:Human
Target:UFM1
Synonyms:Ubiquitin-fold modifier 1, UFM1, C13orf20, BM-002, bA131P10.1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The UFM1 solution (1 mg/ml) 20mM Tris buffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSKVSFKITL TSDPRLPYKV LSVPESTPFT AVLKFAAEEF KVPAATSAII TNDGIGINPA QTAGNVFLKH GSELRIIPRD RVG

UFM1 is a ubiquitin-like protein which is conjugated to target proteins by E1-like activating enzyme UBA5 and E2-like conjugating enzyme UFC1 in a manner equivalent to ubiquitylation. UFM1 localizes principally to the nucleus, but is also present in diffuse amounts in the cytoplasm. UFM1 is expressed in a variety of tissues, including kidney, brain, heart, liver and lung.

UFM1 Human Recombinant fused with a20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing103 amino acids (1-83 a.a) and having a molecular mass of 11.1kDa. The UFM1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable).
NCBI Summary:UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M; MIM 603173) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Dec 2008]
UniProt Code:P61960
NCBI GenInfo Identifier:7705300
NCBI Gene ID:51569
NCBI Accession:NP_057701
UniProt Secondary Accession:P61960,Q14346, Q5VXS0, Q6IAG6, Q9CPX2, Q9NZF2,
UniProt Related Accession:P61960
Molecular Weight:11.1 kDa (103aa), confirmed by MALDI-TOF
NCBI Full Name:ubiquitin-fold modifier 1 isoform 1
NCBI Synonym Full Names:ubiquitin fold modifier 1
NCBI Official Symbol:UFM1  
NCBI Official Synonym Symbols:BM-002; C13orf20  
NCBI Protein Information:ubiquitin-fold modifier 1
UniProt Protein Name:Ubiquitin-fold modifier 1
Protein Family:Ufm1-specific protease
UniProt Gene Name:UFM1  
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